Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Fosphenytoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fosphenytoin SCHEMBL9843479 | 0.99 | POLB (0.51) | POLBTDP1NPC1HRH1HRH3 | |
| SCHEMBL1725500 | 0.88 | POLB (0.55) | POLBTDP1NPC1HRH1HRH3 | |
| Fosphenytoin SCHEMBL94254 | 0.86 | POLB (0.56) | POLBTDP1NPC1HRH1HRH3 | |
| Fosphenytoin SCHEMBL20769774 | 0.86 | POLB (0.56) | POLBTDP1NPC1HRH1HRH3 | |
| Fosphenytoin SCHEMBL1560790 | 0.84 | POLB (0.55) | POLBTDP1NPC1HRH1HRH3 | |
| Fosphenytoin SCHEMBL318673 | 0.84 | POLB (0.55) | POLBTDP1NPC1HRH1HRH3 | |
| Fosphenytoin SCHEMBL7205444 | 0.84 | POLB (0.55) | POLBTDP1NPC1HRH1HRH3 | |
| SCHEMBL7854954 | 0.83 | POLB (0.53) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL5441087 | 0.82 | POLB (0.52) | POLBTDP1NPC1HRH1HRH3 | |
| SCHEMBL8056128 | 0.82 | POLB (0.55) | POLBTDP1NPC1HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2800 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20250281477-A1 | TREATMENT OF CNS CONDITIONS | TAKEDA PHARMACEUTICALS CO (JP) | 2025-09-11 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| CN-119732904-A | Sodium fosphenytoin injection and preparation method thereof | 科诺凯医药科技(四川)有限公司 | 2025-04-01 | — | — | CN | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| CN-119528984-A | Preparation method of fosphenytoin sodium | 广安凯特制药有限公司 | 2025-02-28 | — | — | CN | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| CN-118161457-A | Solid composition of fosphenytoin sodium, freeze-drying method and application thereof | 四川科瑞德制药股份有限公司 | 2024-06-11 | — | — | CN | claimed |
| CN-114588116-B | Solid composition of fosphenytoin sodium, freeze-drying method and application thereof | 四川科瑞德制药股份有限公司 | 2024-03-15 | — | — | CN | claimed |
| WO-2006078524-A1 | METHODS FOR QT INTERVAL CONTROL | JANSSEN PHARMACUTICA, N.V. (BE) | 2006-07-27 | — | — | WO | claimed |
| WO-2006079055-A2 | APPARATUS AND METHOD FOR DELIVERING THERAPEUTIC AND/OR OTHER AGENTS TO THE INNER EAR AND TO OTHER TISSUES | NEUROSYSTEC CORPORATION (US) | 2006-07-27 | — | — | WO | claimed |
| CN-1263454-C | Fosphenytoin sodium powder for injection and its prepn | TIANJIN INST OF MATETIA MEDICA (CN) | 2006-07-12 | — | — | CN | claimed |
| US-20060104968-A1 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases | HALOZYME, INC. (US) | 2006-05-18 | — | — | US | claimed |
| US-20050272706-A1 | Process for the preparation of sodium fosphenytoin | CILAG, LTD. | 2005-12-08 | — | — | US | claimed |
| US-20050260186-A1 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases | HALOZYME, INC. (US) | 2005-11-24 | — | — | US | claimed |
| CN-1608626-A | Fosphenytoin sodium powder for injection and its prepn | TIANJIN INST OF MATETIA MEDICA (CN) | 2005-04-27 | — | — | CN | claimed |
| CN-1555805-A | Ortho diphenylhydratoin freeze dried powder for injection and its preparation method | 陈庆财 | 2004-12-22 | — | — | CN | claimed |
| WO-1999004798-A1 | LYOPHILIZED FOSPHENYTOIN SODIUM FOR PARENTERAL USE | WARNER-LAMBERT COMPANY (US) | 1999-02-04 | — | — | WO | claimed |
| EP-0427925-A2 | Use of prophenytoin for preparing pharmaceutical preparations for treating stroke and cerebral ischemia | WARNER-LAMBERT COMPANY (US) | 1991-05-22 | — | — | EP | claimed |