Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Fosphenytoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fosphenytoin SCHEMBL94254 | 0.99 | POLB (0.56) | POLBTDP1NPC1MEN1KMT2A | |
| Fosphenytoin SCHEMBL20769774 | 0.99 | POLB (0.56) | POLBTDP1NPC1MEN1KMT2A | |
| Fosphenytoin SCHEMBL318673 | 0.97 | POLB (0.55) | POLBTDP1NPC1MEN1KMT2A | |
| Fosphenytoin SCHEMBL1560790 | 0.97 | POLB (0.55) | POLBTDP1NPC1MEN1KMT2A | |
| Fosphenytoin SCHEMBL28132875 | 0.94 | POLB (0.49) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL2615240 | 0.91 | POLB (0.49) | POLBTDP1NPC1MEN1KMT2A | |
| Fosphenytoin SCHEMBL5798533 | 0.90 | CYP2C9 (0.52) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL18775360 | 0.88 | POLB (0.51) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL1725500 | 0.87 | POLB (0.55) | POLBTDP1NPC1MEN1KMT2A | |
| Fosphenytoin SCHEMBL9843479 | 0.86 | POLB (0.51) | POLBTDP1NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986403-B1 | COMPOSITION WITH EXTENDED SHELF-LIFE STORAGE COMPRISING CYCLODEXTRIN AND DRUGS OR PRODRUGS THAT DECOMPOSE TO WATER-INSOLUBLE COMPONENTS | CYDEX INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6133248-A | COMPOSITION COMPRISING CYCLODEXTRIN, FOSPHENYTOIN AND A PHARMACEUTICALLY ACCEPTABLE CARRIER, WHEREIN THE CYCLODEXTRIN IS PRESENT AT LESS THAN 75% EQUIMOLAR AMOUNTS OF THE FOSPHENYTOIN | CYDEX, INC. (US) | 2000-10-17 | — | — | US | disclosed |
| EP-0986403-A1 | POLAR DRUG OR PRODRUG COMPOSITIONS WITH EXTENDED SHELF-LIFE STORAGE AND A METHOD OF MAKING THEREOF | Cydex Inc. (US) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998056422-A1 | POLAR DRUG OR PRODRUG COMPOSITIONS WITH EXTENDED SHELF-LIFE STORAGE AND A METHOD OF MAKING THEREOF | THE UNIVERSITY OF KANSAS (US) | 1998-12-17 | — | — | WO | disclosed |