2-Methoxyestradiol

2-Methoxyestradiol

SCHEMBL119439

COc1cc2c(cc1O)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@H](O)CC[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 5/20 1.00
CYP1A2 P05177 2/20 1.00
CYP3A4 P08684 2/20 1.00
HSD17B10 Q99714 2/20 1.00
CYP1A1 P04798 2/20 1.00
CYP1B1 Q16678 2/20 1.00
MEN1 O00255 2/20 1.00
LMNA P02545 2/20 1.00
GAA P10253 2/20 1.00
MAPT P10636 2/20 1.00
KMT2A Q03164 2/20 1.00
SHBG P04278 2/20 1.00
TP53 P04637 1/20 1.00
TSHR P16473 1/20 1.00
NFKB1 P19838 1/20 1.00
CYP2C19 P33261 1/20 1.00
THPO P40225 1/20 1.00
GMNN O75496 1/20 1.00
MTOR P42345 1/20 1.00
BLM P54132 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Methoxyestradiol SCHEMBL13123068 1.00 CYP19A1 (1.00) CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1
2-Methoxyestradiol SCHEMBL2610023 1.00 CYP19A1 (1.00) CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1
2-Methoxyestradiol SCHEMBL8796 1.00 CYP19A1 (1.00) CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1
2-Methoxyestradiol SCHEMBL26936622 1.00 CYP19A1 (1.00) CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1
2-Methoxyestradiol SCHEMBL14252882 1.00 CYP19A1 (1.00) CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1
2-Methoxyestradiol SCHEMBL23261536 1.00 CYP19A1 (1.00) CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1
2-Methoxyestradiol SCHEMBL7052497 1.00 CYP19A1 (1.00) CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1
2-Methoxyestradiol SCHEMBL29357742 1.00 CYP19A1 (1.00) CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1
SCHEMBL8489736 0.95 CYP1A1 (1.00) CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1
SCHEMBL4896510 0.95 CYP1A1 (1.00) CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2318 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3984537-B1 CANCER TREATMENTS USING COMBINATIONS OF TYPE 2 MEK AND ERK INHIBITORS BIOMED VALLEY DISCOVERIES INC (US) 2024-03-20 EP claimed
EP-4257134-A2 COMBINING ANTI-HLA-DR OR ANTI-TROP-2 ANTIBODIES WITH MICROTUBULE INHIBITORS, PARP INHIBITORS, BRUTON KINASE INHIBITORS OR PHOSPHOINOSITIDE 3-KINASE INHIBITORS SIGNIFICANTLY IMPROVES THERAPEUTIC OUTCOME IN CANCER Immunomedics, Inc. (US) 2023-10-11 EP claimed
EP-3313443-B9 COMBINING ANTI-HLA-DR OR ANTI-TROP-2 ANTIBODIES WITH MICROTUBULE INHIBITORS, PARP INHIBITORS, BRUTON KINASE INHIBITORS OR PHOSPHOINOSITIDE 3-KINASE INHIBITORS SIGNIFICANTLY IMPROVES THERAPEUTIC OUTCOME IN CANCER IMMUNOMEDICS INC (US) 2023-10-04 EP claimed
EP-3313443-B1 COMBINING ANTI-HLA-DR OR ANTI-TROP-2 ANTIBODIES WITH MICROTUBULE INHIBITORS, PARP INHIBITORS, BRUTON KINASE INHIBITORS OR PHOSPHOINOSITIDE 3-KINASE INHIBITORS SIGNIFICANTLY IMPROVES THERAPEUTIC OUTCOME IN CANCER IMMUNOMEDICS INC (US) 2023-06-07 EP claimed
US-20230056203-A1 METHODS AND COMPOSITIONS FOR TARGETING CANCER CELLS IN METASTASES THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-02-23 US claimed
US-20210154200-A1 7-BENZYL-4-(METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO[1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5 (1H)-ONE, SALTS THEREOF AND METHODS OF USING THE SAME IN COMBINATION THERAPY ONCOCEUTICS, INC. (US) 2021-05-27 US claimed
US-10988539-B2 Combination therapy with anti-HLA-DR antibodies and kinase inhibitors in hematopoietic cancers IMMUNOMEDICS, INC. (US) 2021-04-27 US claimed
WO-2021067403-A1 BIOMARKERS FOR ANTIBODY-DRUG CONJUGATE MONOTHERAPY OR COMBINATION THERAPY IMMUNOMEDICS, INC. (US) 2021-04-08 WO claimed
US-20210093730-A1 BIOMARKERS FOR ANTIBODY-DRUG CONJUGATE MONOTHERAPY OR COMBINATION THERAPY IMMUNOMEDICS, INC. 2021-04-01 US claimed
US-10745479-B2 TM4SF1 binding proteins and methods of using same BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2020-08-18 US claimed
WO-2000076487-A2 USE OF PACLITAXEL AND STERIOD DERIVATIVES AS AROMATASE INHIBITORS FOR THE TREATMENT OF CANCER STERIX LIMITED (GB) 2000-12-21 WO claimed
WO-2000048606-A1 COMPOSITIONS AND METHODS FOR USE IN TARGETING VASCULAR DESTRUCTION OXIGENE, INC. (US) 2000-08-24 WO claimed
JP-2000507923-A 2000-06-27 JP claimed
EP-0833641-A4 TREATMENT AND PREVENTION OF PROSTATIC DISEASE MERCK & CO INC (US) 2000-04-05 EP claimed
US-5962445-A Treatment of asthma and airway diseases AMRAD OPERATIONS PTY LTD. (AU) 1999-10-05 US claimed
EP-0923376-A1 TREATMENT OF ASTHMA AND AIRWAY DISEASES Amrad Operations Pty.,Ltd. (AU) 1999-06-23 EP claimed
WO-1999001142-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ANGIOSTATIC STEROID COMBINED WITH A HYALURONAN HYAL PHARMACEUTICAL CORPORATION (CA) 1999-01-14 WO claimed
EP-0833641-A1 TREATMENT AND PREVENTION OF PROSTATIC DISEASE Merck & Co., Inc. (US) 1998-04-08 EP claimed
WO-1997042958-A1 TREATMENT OF ASTHMA AND AIRWAY DISEASES AMRAD OPERATIONS PTY. LTD. (AU) 1997-11-20 WO claimed
WO-1996040150-A1 TREATMENT AND PREVENTION OF PROSTATIC DISEASE MERCK & CO., INC. (US) 1996-12-19 WO claimed