Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | CYP1A1 | P04798 | 2/20 | 1.00 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SHBG | P04278 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | MTOR | P42345 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Methoxyestradiol SCHEMBL13123068 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1 | |
| 2-Methoxyestradiol SCHEMBL2610023 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1 | |
| 2-Methoxyestradiol SCHEMBL8796 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1 | |
| 2-Methoxyestradiol SCHEMBL119439 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1 | |
| 2-Methoxyestradiol SCHEMBL14252882 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1 | |
| 2-Methoxyestradiol SCHEMBL23261536 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1 | |
| 2-Methoxyestradiol SCHEMBL7052497 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1 | |
| 2-Methoxyestradiol SCHEMBL29357742 | 1.00 | CYP19A1 (1.00) | CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1 | |
| SCHEMBL8489736 | 0.95 | CYP1A1 (1.00) | CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1 | |
| SCHEMBL4896510 | 0.95 | CYP1A1 (1.00) | CYP19A1CYP1A2CYP3A4HSD17B10CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307265-B1 | PHARMACEUTICAL COMBINATION AND USES THEREOF | BIONOMICS LTD (AU) | 2023-12-13 | — | — | EP | disclosed |