Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.44 |
| ▸ | POLA1 | P09884 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 9/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 3/20 | 0.41 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
| ▸ | CCNH | P51946 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11946766 | 0.90 | POLA1 (0.46) | CDK2POLA1CDK1CCNB1CCNT1 | |
| SCHEMBL4106064 | 0.88 | CYP2C19 (0.48) | CDK2POLA1CDK1CCNB1PDPK1 | |
| SCHEMBL11946763 | 0.85 | POLA1 (0.44) | CDK2POLA1CDK1CCNB1CCNT1 | |
| SCHEMBL11947245 | 0.82 | POLA1 (0.47) | CDK2POLA1CDK1CCNB1CCNT1 | |
| SCHEMBL4110794 | 0.78 | PDPK1 (0.43) | CDK2POLA1CDK1CCNB1PDPK1 | |
| SCHEMBL4098291 | 0.78 | CYP2C19 (0.51) | CDK2POLA1CDK1CCNB1CCNA2 | |
| SCHEMBL4106873 | 0.74 | CYP2C19 (0.47) | CDK2POLA1CDK1CCNB1CCNA2 | |
| SCHEMBL11946764 | 0.74 | CSF1R (0.41) | CDK2CCNA2BRAFCCNA1ROCK2 | |
| SCHEMBL4110137 | 0.74 | NEK2 (0.46) | CDK2POLA1CDK1CCNB1CCNA2 | |
| SCHEMBL13798618 | 0.72 | CDK2 (0.45) | CDK2POLA1CDK1CCNB1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220091-B1 | REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES INC (US) | 2012-07-25 | — | — | EP | disclosed |
| WO-2009079412-A2 | REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2009-06-25 | — | — | WO | disclosed |