Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 10/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CCNH | P51946 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4105100 | 0.90 | CYP2C9 (0.51) | CDK2CDK1CCNB1CCNA2CCNB2 | |
| SCHEMBL13561268 | 0.83 | CYP2C9 (0.55) | CDK2CDK1CCNB1CCNA2CCNB2 | |
| SCHEMBL11947340 | 0.81 | CYP2C9 (0.46) | CDK2CDK1CCNB1CCNA2CCNB2 | |
| SCHEMBL10256560 | 0.78 | CYP2C9 (0.44) | CDK2CDK1CCNB1CCNA2CCNB2 | |
| SCHEMBL11946763 | 0.74 | POLA1 (0.44) | CDK2BRAFCDK1CCNB1CCNA2 | |
| SCHEMBL4110978 | 0.74 | CYP2C9 (0.57) | CDK2CDK1CCNB1CCNA2CCNB2 | |
| SCHEMBL13798701 | 0.74 | CYP2C9 (0.41) | CYP2C9CYP2C19 | |
| SCHEMBL11946985 | 0.72 | CDK2 (0.44) | CDK2BRAFCDK1CCNB1CCNA2 | |
| SCHEMBL13561283 | 0.71 | CYP2C9 (0.50) | BRAFKDM4ENPC1HPGDRAB9A | |
| SCHEMBL13561275 | 0.71 | CDK1 (0.55) | CDK2CDK1CCNB1CCNA2CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009079412-A2 | REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2009-06-25 | — | — | WO | disclosed |