Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 5/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 7/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11949298 | 0.89 | STAT3 (0.40) | HDAC4HDAC6S1PR1SMPD1STAT3 | |
| SCHEMBL15150652 | 0.84 | GABRA5 (0.39) | HDAC6S1PR1STAT3KDM4EPOLB | |
| SCHEMBL15150659 | 0.83 | POLB (0.40) | HDAC6S1PR1SMPD1STAT3ADAMTS4 | |
| SCHEMBL14973346 | 0.81 | HDAC1 (0.41) | HDAC6STAT3MRGPRX4 | |
| SCHEMBL14973240 | 0.81 | POLB (0.46) | HDAC6S1PR1STAT3ADAMTS4KDM4E | |
| SCHEMBL14984863 | 0.81 | HDAC1 (0.43) | HDAC6KDM4EPOLBLMNA | |
| SCHEMBL14972950 | 0.81 | S1PR1 (0.46) | S1PR1ADAMTS4POLB | |
| SCHEMBL14973342 | 0.80 | GABRA5 (0.41) | HDAC6S1PR1KDM4EPOLBMRGPRX4 | |
| SCHEMBL14973234 | 0.80 | PLAT (0.39) | HDAC6STAT3KDM4EPOLBMRGPRX4 | |
| SCHEMBL14973166 | 0.80 | HDAC1 (0.41) | HDAC6S1PR1STAT3KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012099200-A1 | PYRAZOLE DERIVATIVE | 大正製薬株式会社 (JP) | 2012-07-26 | — | — | WO | disclosed |