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GABRA5

Gamma-aminobutyric acid receptor subunit alpha-5 · P31644 · GABRA5 on Sugi Atlas →

207,535 patent compounds predicted against GABRA5, 96,506 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL107225 SCHEMBL107225 1.00 20/20
SCHEMBL109273 SCHEMBL109273 1.00 20/20
SCHEMBL108921 SCHEMBL108921 0.84 20/20
SCHEMBL108791 SCHEMBL108791 0.82 20/20
SCHEMBL107148 SCHEMBL107148 0.77 20/20
SCHEMBL107245 SCHEMBL107245 0.76 20/20
SCHEMBL106221 SCHEMBL106221 0.75 20/20
SCHEMBL110035 SCHEMBL110035 0.75 20/20
SCHEMBL107815 SCHEMBL107815 0.65 20/20
SCHEMBL108484 SCHEMBL108484 0.63 20/20
SCHEMBL15406 SCHEMBL15406 0.61 20/20
Fipronil Fipronil (SCHEMBL15088) 0.59 20/20
SCHEMBL41972 SCHEMBL41972 0.59 20/20
Fipronil Fipronil (SCHEMBL44222) 0.59 20/20
SCHEMBL109043 SCHEMBL109043 0.58 20/20
Ethiprole Ethiprole (SCHEMBL27048) 0.56 20/20
SCHEMBL25897 SCHEMBL25897 0.51 20/20
SCHEMBL107197 SCHEMBL107197 0.50 20/20
SCHEMBL108887 SCHEMBL108887 0.77 19/20
SCHEMBL103674 SCHEMBL103674 0.60 19/20

Clinical trials — most relevant to GABRA5 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Computational Assessment of GABA Receptor Modulation in PTSD PHASE4RECRUITING
Safety of Ramelteon in Elderly Subjects PHASE4COMPLETED
Attenuate the Stress Response in Laparoscopic Cholecystectomy PHASE4NOT_YET_RECRUITING
The Effects of Levetiracetam on Alcohol Dependent Subjects PHASE4COMPLETED
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence. PHASE4COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia PHASE3COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia PHASE2COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia PHASE2COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy PHASE1/PHASE2WITHDRAWN
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome PHASE2RECRUITING
Open Label, Adaptive, Parallel Group PET Study Using RO7017773 And [11C] RO15-4513 PHASE1COMPLETED
PET Imaging of Brain Peripheral Benzodiazepine Receptors PHASE1COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T EARLY_PHASE1UNKNOWN
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression EARLY_PHASE1RECRUITING
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain nanRECRUITING
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy nanENROLLING_BY_INVITATION
GABA Biomarkers in Dravet Syndrome nanRECRUITING
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy nanUNKNOWN
Assessment of Peripheral GABA Receptors for Local Pain Relief nanUNKNOWN
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. nanCOMPLETED
Mechanisms of Human Plasticity in the Human System nanCOMPLETED
Effects of Flumazenil on Brain Excitability nanCOMPLETED
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Brain Changes in Patients With Focal Hand Dystonia nanCOMPLETED
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk nanCOMPLETED
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA) nanCOMPLETED
Effect of Gabapentin on GABA Concentration and Emotional Processing nanCOMPLETED
Remifentanil and Remimazolam to Limit Patient Movement nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a GABRA5 binder may also engage these)

ProteinNameSimilarity
P19969 — 0.998 P19969 →
Q8BHJ7 — 0.996 Q8BHJ7 →
Q08E50 — 0.996 Q08E50 →
P62812 — 0.988 P62812 →
P62813 — 0.988 P62813 →
P08219 — 0.987 P08219 →
Q4R534 — 0.987 Q4R534 →
Q5R6B2 — 0.986 Q5R6B2 →
P19150 — 0.985 P19150 →
GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 0.979 landscape →
P23576 — 0.977 P23576 →
P26049 — 0.971 P26049 →
P10063 — 0.971 P10063 →
Q5RCC5 — 0.969 Q5RCC5 →
P10064 — 0.968 P10064 →
P20236 — 0.968 P20236 →
P26048 — 0.968 P26048 →
GABRB1 Gamma-aminobutyric acid receptor subunit beta-1 0.966 landscape →
GABRA2 Gamma-aminobutyric acid receptor subunit alpha-2 0.966 landscape →
GABRA3 Gamma-aminobutyric acid receptor subunit alpha-3 0.966 landscape →
P15431 — 0.964 P15431 →
P50571 — 0.964 P50571 →
P63079 — 0.963 P63079 →
GABRB3 Gamma-aminobutyric acid receptor subunit beta-3 0.962 landscape →
P63080 — 0.961 P63080 →
P08220 — 0.961 P08220 →
P18508 — 0.960 P18508 →
P19019 — 0.958 P19019 →
P0C2W5 — 0.957 P0C2W5 →
Q5REA1 — 0.956 Q5REA1 →