Sugi Predict

Sugi Predict / Compounds / SCHEMBL1195000

SCHEMBL1195000

SCHEMBL1195000

CCCCCS(=O)(=O)CC(=O)O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 3/20 0.58
▸ CES2 O00748 2/20 0.58
▸ CES1 P23141 1/20 0.58
▸ POLB P06746 1/20 0.52
▸ CA2 P00918 1/20 0.48
▸ AKR1B1 P15121 1/20 0.46
▸ GPR84 Q9NQS5 7/20 0.44
▸ PPARG P37231 7/20 0.44
▸ PPARD Q03181 7/20 0.44
▸ PPARA Q07869 7/20 0.44
▸ HDAC11 Q96DB2 5/20 0.44
▸ TSHR P16473 4/20 0.44
▸ PTPN1 P18031 3/20 0.44
▸ ALDH1A1 P00352 2/20 0.44
▸ TLR2 O60603 2/20 0.44
▸ TDP1 Q9NUW8 2/20 0.44
▸ FABP4 P15090 2/20 0.44
▸ SLC22A6 Q4U2R8 1/20 0.44
▸ SLC22A8 Q8TCC7 1/20 0.44
▸ MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27682546 0.98 FAAH (0.61) FAAHCES2CES1POLBCA2
SCHEMBL29035989 0.98 FAAH (0.61) FAAHCES2CES1POLBCA2
SCHEMBL4813130 0.98 FAAH (0.61) FAAHCES2CES1POLBCA2
SCHEMBL27517944 0.98 FAAH (0.61) FAAHCES2CES1POLBCA2
SCHEMBL5141666 0.98 FAAH (0.61) FAAHCES2CES1POLBCA2
SCHEMBL3729622 0.98 FAAH (0.61) FAAHCES2CES1POLBCA2
SCHEMBL4592216 0.93 POLB (0.55) FAAHCES2CES1POLBCA2
SCHEMBL6233385 0.85 POLB (0.63) FAAHCES2CES1POLBCA2
SCHEMBL6236955 0.85 POLB (0.63) FAAHCES2CES1POLBCA2
SCHEMBL3159562 0.83 POLB (0.60) FAAHCES2CES1POLBAKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8889696-B2 Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof Temple University—Of the Commonwealth System of Higher Education (US) 2014-11-18 — — US claimed
US-20120269831-A1 SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2012-10-25 — — US claimed
EP-2512250-A1 SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF Temple University - Of The Commonwealth System of Higher Education (US) 2012-10-24 — — EP claimed
WO-2011075616-A1 SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2011-06-23 — — WO claimed
EP-1604819-B1 Lithographic printing plate precursor FUJIFILM CORP (JP) 2008-04-09 — — EP claimed
EP-1294788-B1 CURABLE AQUEOUS POLYURETHANE DISPERSIONS BASF AG (DE) 2006-06-07 — — EP claimed
US-7029835-B2 Photothermographic element comprising improved base precursors and methods for their use EASTMAN KODAK COMPANY (US) 2006-04-18 — — US claimed
EP-1604819-A2 Lithographic printing plate precursor Fuji Photo Film Co., Ltd. (JP) 2005-12-14 — — EP claimed
US-6974662-B2 Thermal base precursors EASTMAN KODAK COMPANY (US) 2005-12-13 — — US claimed
WO-2005043238-A1 THERMAL BASE PRECURSORS EASTMAN KODAK COMPANY (US) 2005-05-12 — — WO claimed
US-6746807-B1 COLOR PHOTOTHERMOGRAPHIC IMAGING ELEMENT COMPRISING FILTER DYE WHICH UNDERGOES EFFICIENT AND IRREVERSIBLE THERMAL BLEACHING DURING THERMAL PROCESSING AT LOWER TEMPERATURES EASTMAN KODAK COMPANY 2004-06-08 — — US claimed
EP-1422553-A1 Improved base precursors for use in a photothermographic element EASTMAN KODAK COMPANY (US) 2004-05-26 — — EP claimed
US-20040096758-A1 THERMALLY BLEACHABLE FILTER DYE COMPOSITIONS COMPRISING BENZOTHIAZINE-DIOXIDE ARYLIDENE DYES AND BASE PRECURSORS FOR USE IN A PHOTOTHERMOGRAPHIC ELEMENT EASTMAN KODAK COMPANY 2004-05-20 — — US claimed
US-6730462-B1 Thermally bleachable yellow filter dye compositions barbituric acid arylidene dyes and base precursors EASTMAN KODAK COMPANY 2004-05-04 — — US claimed
US-6699651-B1 THERMALLY BLEACHABLE FILTER DYE COMPOSITIONS COMPRISING A BASE PRECURSOR THAT IS THE SALT OF AN ORGANIC BASE WITH AN ARYLSULFONYLACETIC ACID EASTMAN KODAK COMPANY 2004-03-02 — — US claimed
US-6596455-B2 On a water receptive substrate, a heat-sensitive layer comprising microcapsules containing a compound having thermally reactive functional group, which reacts with a compound in the light sensitive layer; storage stability FUJI PHOTO FILM CO., LTD. (JP) 2003-07-22 — — US claimed
US-20010046638-A1 On a water receptive substrate, a heat-sensitive layer comprising microcapsules containing a compound having thermally reactive functional group, which reacts with a compound in the light sensitive layer; storage stability FUJIFILM CORPORATION (JP) 2001-11-29 — — US claimed
EP-1147885-A2 Lithographic printing plate precursor FUJI PHOTO FILM CO., LTD. (JP) 2001-10-24 — — EP claimed
EP-0675003-B1 Thermal transfer imaging MINNESOTA MINING & MFG (US) 1997-09-10 — — EP claimed
EP-0675003-A1 Thermal transfer imaging MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1995-10-04 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120269831-A1 SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF MKI67, CCNA1, FOLR1 FAAH 4091/4885CES2 4040/4885CES1 2465/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.