Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | BRAF | P15056 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1195762 | 0.85 | BRAF (0.68) | MAPTMEN1KMT2ANPSR1HSP90AB1 | |
| SCHEMBL1776866 | 0.85 | BRAF (0.79) | MAPTMEN1KMT2ANPSR1HSP90AB1 | |
| SCHEMBL1195193 | 0.84 | MEN1 (0.64) | MAPTMEN1KMT2ANPSR1HSP90AB1 | |
| SCHEMBL1775711 | 0.84 | BRAF (0.81) | MAPTMEN1KMT2ANPSR1HSP90AB1 | |
| SCHEMBL12873669 | 0.84 | KMT2A (0.62) | MAPTMEN1KMT2ANPSR1HSP90AB1 | |
| SCHEMBL12888636 | 0.83 | MEN1 (0.66) | MAPTMEN1KMT2ANPSR1HSP90AB1 | |
| SCHEMBL12889083 | 0.82 | MEN1 (0.65) | MAPTMEN1KMT2ANPSR1HSP90AB1 | |
| SCHEMBL12888639 | 0.81 | ALDH1A1 (0.62) | MAPTMEN1KMT2ANPSR1HSP90AB1 | |
| SCHEMBL12888663 | 0.80 | MEN1 (0.59) | MAPTMEN1KMT2ANPSR1HSP90AB1 | |
| SCHEMBL12889057 | 0.79 | KMT2A (0.58) | MAPTMEN1KMT2ANPSR1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034457-A1 | Pyridothiophene Compounds | VERNALIS (CAMBRIDGE) LIMITED. (GB) | 2011-02-10 | — | — | US | disclosed |
| US-20070213328-A1 | Pyridothiophene Compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-09-13 | — | — | US | disclosed |
| EP-1680108-A1 | PYRIDOTHIOPHENE COMPOUNDS | Vernalis (Cambridge) Limited (GB) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005034950-A1 | PYRIDOTHIOPHENE COMPOUNDS | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2005-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213328-A1 | Pyridothiophene Compounds | ALK, HSP90AB1, HSP90AA1 | MAPT 881/4885MEN1 3417/4885KMT2A 854/4885 |
| US-20110034457-A1 | Pyridothiophene Compounds | ALK, HSP90AB1, HSP90AA1 | MAPT 866/4885MEN1 3418/4885KMT2A 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.