Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.65 |
| ▸ | FLT3 | P36888 | 20/20 | 0.65 |
| ▸ | JAK3 | P52333 | 11/20 | 0.65 |
| ▸ | TYK2 | P29597 | 8/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | CDK2 | P24941 | 14/20 | 0.63 |
| ▸ | JAK1 | P23458 | 8/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.63 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | STK16 | O75716 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PRKCB | P05771 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
| ▸ | FER | P16591 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108240 | 0.90 | JAK2 (0.82) | JAK2FLT3JAK3TYK2CYP2D6 | |
| SCHEMBL1108237 | 0.90 | JAK2 (0.82) | JAK2FLT3JAK3TYK2CYP2D6 | |
| SCHEMBL18780727 | 0.84 | JAK2 (0.60) | JAK2FLT3JAK3TYK2CYP2D6 | |
| SCHEMBL18780731 | 0.84 | JAK2 (0.60) | JAK2FLT3JAK3TYK2CYP2D6 | |
| SCHEMBL1108236 | 0.83 | JAK2 (0.87) | JAK2FLT3JAK3TYK2CYP2D6 | |
| SCHEMBL1108245 | 0.83 | JAK2 (0.87) | JAK2FLT3JAK3TYK2CYP2D6 | |
| SCHEMBL14538672 | 0.81 | JAK2 (0.79) | JAK2FLT3JAK3TYK2CYP2D6 | |
| SCHEMBL14538675 | 0.81 | JAK2 (0.79) | JAK2FLT3JAK3TYK2CYP2D6 | |
| SCHEMBL1108286 | 0.81 | JAK2 (0.81) | JAK2FLT3JAK3TYK2CYP2D6 | |
| SCHEMBL17573432 | 0.80 | JAK2 (0.67) | JAK2FLT3JAK3TYK2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415338-B2 | Oxygen linked pyrimidine derivatives | CELL THERAPEUTICS, INC. (US) | 2013-04-09 | — | — | US | disclosed |
| US-8415338-B2 | Oxygen linked pyrimidine derivatives | CELL THERAPEUTICS, INC. (US) | 2013-04-09 | — | — | US | disclosed |
| US-20120196855-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2012-08-02 | — | — | US | disclosed |
| US-20120196855-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2012-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196855-A1 | OXYGEN LINKED PYRIMIDINE DERIVATIVES | DPYD, TK2, TK1 | JAK2 468/4885FLT3 645/4885JAK3 557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.