Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | STAT1 | P42224 | 1/20 | 0.64 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28549138 | 0.95 | ABCG2 (0.71) | ABCG2MEN1KMT2APOLBMAPT | |
| SCHEMBL3192412 | 0.88 | ABCG2 (0.69) | ABCG2MEN1KMT2APOLBMAPT | |
| SCHEMBL3192428 | 0.88 | ABCG2 (0.69) | ABCG2MEN1KMT2APOLBMAPT | |
| SCHEMBL3173761 | 0.88 | TNFRSF1A (0.72) | ABCG2ABCB1MAPTALDH1A1CYP3A4 | |
| SCHEMBL3173746 | 0.88 | TNFRSF1A (0.72) | ABCG2ABCB1MAPTALDH1A1CYP3A4 | |
| SCHEMBL28553855 | 0.86 | MAPT (0.79) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL108665 | 0.86 | MAPT (0.79) | MAPTALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13776922 | 0.85 | MAPT (0.86) | ABCG2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2458577 | 0.84 | ABCG2 (1.00) | ABCG2MEN1KMT2AABCB1MAPT | |
| SCHEMBL2458579 | 0.84 | ABCG2 (1.00) | ABCG2MEN1KMT2AABCB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023567-A1 | Novel Compounds | SPEAR THERAPEUTICS LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| US-20130023567-A1 | Novel Compounds | SPEAR THERAPEUTICS LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
| US-8236827-B2 | Compounds | SPEAR THERAPEUTICS LIMITED (GB) | 2012-08-07 | — | — | US | disclosed |
| US-8236827-B2 | Compounds | SPEAR THERAPEUTICS LIMITED (GB) | 2012-08-07 | — | — | US | disclosed |
| US-20100168180-A1 | Novel Compounds | SPEAR THERAPEUTICS LIMITED (GB) | 2010-07-01 | — | — | US | disclosed |
| US-20100168180-A1 | Novel Compounds | SPEAR THERAPEUTICS LIMITED (GB) | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168180-A1 | Novel Compounds | HRAS, MCL1, KRAS | ABCG2 1608/4885MEN1 370/4885KMT2A 1361/4885 |
| US-20130023567-A1 | Novel Compounds | MKI67, RB1, CCND1 | ABCG2 1606/4885MEN1 1191/4885KMT2A 1031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.