Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 4/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.45 |
| ▸ | RELA | Q04206 | 4/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20429152 | 1.00 | NFKB1 (0.45) | NFKB1NFKB2RELAKDM1ABTK | |
| SCHEMBL12035428 | 1.00 | NFKB1 (0.45) | NFKB1NFKB2RELAKDM1ABTK | |
| SCHEMBL21294876 | 0.91 | NFKB1 (0.49) | NFKB1NFKB2RELAKDM1ABTK | |
| SCHEMBL4270316 | 0.91 | NFKB1 (0.49) | NFKB1NFKB2RELAKDM1ABTK | |
| SCHEMBL4270314 | 0.91 | NFKB1 (0.49) | NFKB1NFKB2RELAKDM1ABTK | |
| SCHEMBL20063806 | 0.91 | NFKB1 (0.49) | NFKB1NFKB2RELAKDM1ABTK | |
| SCHEMBL763965 | 0.91 | NFKB1 (0.49) | NFKB1NFKB2RELAKDM1ABTK | |
| SCHEMBL1503811 | 0.84 | NFKB1 (0.44) | NFKB1NFKB2RELAKDM1ABTK | |
| SCHEMBL1503805 | 0.84 | NFKB1 (0.44) | NFKB1NFKB2RELAKDM1ABTK | |
| SCHEMBL15045018 | 0.84 | NFKB1 (0.44) | NFKB1NFKB2RELAKDM1ABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1405852-B1 | DIAMINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2012-08-01 | — | — | EP | disclosed |
| EP-2343290-A1 | Diamine derivatives as factor X inhibitors | Daiichi Sankyo Company, Limited (JP) | 2011-07-13 | — | — | EP | disclosed |