Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28676774 | 0.83 | KDM4E (0.53) | KDM4ERAB9AFKBP1ANPC1ALDH1A1 | |
| SCHEMBL2801746 | 0.83 | KDM4E (0.53) | KDM4EFKBP1AKMT2AHTTL3MBTL1 | |
| SCHEMBL11960940 | 0.82 | JAK1 (0.46) | TP53KMT2AHTTCYP2C9 | |
| SCHEMBL28688512 | 0.79 | MAPT (0.52) | KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL2800316 | 0.78 | ROCK1 (0.71) | KDM4EFKBP1ANPC1ALDH1A1KMT2A | |
| SCHEMBL16464339 | 0.78 | KDM4E (0.50) | KDM4EFKBP1AHPGDNPC1ALDH1A1 | |
| SCHEMBL2562792 | 0.76 | RAB9A (0.57) | KDM4ERAB9ASMN1; SMN2FKBP1ATP53 | |
| SCHEMBL10174349 | 0.76 | MAPT (0.68) | RAB9ASMN1; SMN2FKBP1ATP53MAPK1 | |
| SCHEMBL256984 | 0.75 | TSHR (0.57) | KDM4ERAB9ATP53HPGDNPC1 | |
| SCHEMBL7872429 | 0.75 | MAPT (0.57) | RAB9ANPC1KMT2AHTTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155201-B1 | QUINOXALINE DERIVATIVES AS INHIBITORS OF THE TYROSINE KINASE ACTIVITY OF JANUS KINASES | NOVARTIS AG (CH) | 2012-08-01 | — | — | EP | disclosed |