Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 9/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3731139 | 0.99 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGCFD | |
| Hydrochloric Acid SCHEMBL3731141 | 0.99 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGCFD | |
| Hydrochloric Acid SCHEMBL3731146 | 0.99 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGCFD | |
| Hydrochloric Acid SCHEMBL3731140 | 0.99 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGCFD | |
| SCHEMBL11961060 | 0.87 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGCFD | |
| Hydrochloric Acid SCHEMBL3735762 | 0.86 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGCFD | |
| Hydrochloric Acid SCHEMBL3735757 | 0.86 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGCFD | |
| Hydrochloric Acid SCHEMBL3735748 | 0.86 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGCFD | |
| Hydrochloric Acid SCHEMBL3735751 | 0.86 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGCFD | |
| SCHEMBL11961057 | 0.85 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGCFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372842-B2 | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-8372842-B2 | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2242757-B1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | CHEK2, CHEK1, BUB1B | PIK3CD 407/4885PIK3CA 361/4885PIK3CB 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.