Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMG1 | Q96Q15 | 4/20 | 0.68 |
| ▸ | JAK2 | O60674 | 8/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | JAK1 | P23458 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667462 | 0.87 | SMG1 (0.65) | SMG1JAK2KCNH2TNIKBRD4 | |
| SCHEMBL30051959 | 0.87 | JAK2 (0.77) | SMG1JAK2CAMK2DJAK3JAK1 | |
| SCHEMBL1667134 | 0.87 | JAK2 (0.77) | SMG1JAK2CAMK2DJAK3JAK1 | |
| SCHEMBL12274387 | 0.78 | SMG1 (0.60) | SMG1JAK2JAK3JAK1CDK1 | |
| SCHEMBL12274999 | 0.77 | CLK1 (0.61) | SMG1JAK2BRD4CDK2 | |
| SCHEMBL25068486 | 0.76 | CCNA2 (0.82) | JAK2KCNH2TNIKBRD4JAK3 | |
| SCHEMBL1670895 | 0.76 | SMG1 (0.51) | SMG1JAK2KCNH2TNIKBRD4 | |
| SCHEMBL12275374 | 0.76 | SMG1 (0.57) | SMG1JAK2CAMK2DJAK3JAK1 | |
| SCHEMBL1670901 | 0.75 | SMG1 (0.51) | SMG1JAK2KCNH2TNIKBRD4 | |
| SCHEMBL2878039 | 0.74 | JAK2 (1.00) | JAK2CAMK2DJAK3JAK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | claimed |
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | disclosed |