Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 13/20 | 0.48 |
| ▸ | JAK3 | P52333 | 8/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670895 | 0.85 | SMG1 (0.51) | SMG1JAK2JAK3JAK1TYK2 | |
| SCHEMBL1667462 | 0.81 | SMG1 (0.65) | SMG1JAK2JAK3JAK1TYK2 | |
| SCHEMBL1670898 | 0.80 | SMG1 (0.50) | SMG1JAK2JAK3JAK1TYK2 | |
| SCHEMBL12921615 | 0.80 | SMG1 (0.50) | SMG1JAK2JAK3JAK1TYK2 | |
| SCHEMBL11962934 | 0.75 | SMG1 (0.68) | SMG1JAK2JAK3JAK1TYK2 | |
| SCHEMBL30051959 | 0.73 | JAK2 (0.77) | SMG1JAK2JAK3JAK1TYK2 | |
| SCHEMBL1667134 | 0.73 | JAK2 (0.77) | SMG1JAK2JAK3JAK1TYK2 | |
| SCHEMBL12275374 | 0.70 | SMG1 (0.57) | SMG1JAK2JAK3JAK1TYK2 | |
| SCHEMBL12921710 | 0.70 | JAK2 (0.49) | SMG1JAK2JAK3JAK1TYK2 | |
| SCHEMBL12948484 | 0.70 | JAK2 (0.54) | SMG1JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | claimed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |