Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 8/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11963297 | 0.86 | CDC7 (0.50) | PDPK1JAK2CDK2 | |
| SCHEMBL2479153 | 0.84 | CDC7 (0.48) | PDPK1JAK2CDK2 | |
| SCHEMBL11963370 | 0.83 | TTK (0.52) | PDPK1JAK2 | |
| SCHEMBL13737545 | 0.82 | KIT (0.52) | PDPK1FLT3 | |
| SCHEMBL31032738 | 0.80 | PDPK1 (0.55) | DYRK1APDPK1JAK2AURKATGFBR1 | |
| SCHEMBL627808 | 0.80 | PDPK1 (0.55) | DYRK1APDPK1JAK2AURKATGFBR1 | |
| SCHEMBL24358638 | 0.80 | MAOA (0.47) | MAOADYRK1ALRRK2KDRSYK | |
| SCHEMBL31134073 | 0.80 | MAOA (0.47) | MAOADYRK1ALRRK2KDRSYK | |
| SCHEMBL11963085 | 0.79 | MAOA (0.51) | MAOAPDPK1JAK2AURKATGFBR1 | |
| SCHEMBL216014 | 0.78 | CNR2 (0.54) | PDPK1JAK2AURKATGFBR1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489663-A1 | Compounds as syk kinase inhibitors | Almirall, S.A. (ES) | 2012-08-22 | — | — | EP | disclosed |