Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098460 | 0.88 | TRPM8 (0.67) | TRPM8 | |
| SCHEMBL1099222 | 0.83 | TRPM8 (0.67) | TRPM8TP53LMNA | |
| SCHEMBL1098367 | 0.78 | TRPM8 (0.65) | TRPM8 | |
| SCHEMBL2060927 | 0.78 | TRPM8 (0.40) | TRPM8HSD11B1MAPTTP53KDM4E | |
| SCHEMBL10280676 | 0.77 | TRPM8 (0.71) | TRPM8 | |
| SCHEMBL1107228 | 0.75 | TRPM8 (0.66) | TRPM8TP53HPGDNPSR1LMNA | |
| SCHEMBL1098524 | 0.74 | TRPM8 (0.64) | TRPM8TP53LMNA | |
| SCHEMBL1098599 | 0.73 | TRPM8 (0.54) | TRPM8TP53LMNA | |
| SCHEMBL10280678 | 0.73 | TRPM8 (0.46) | TRPM8PTPN1HSD11B1MAPTTP53 | |
| SCHEMBL1099116 | 0.73 | TRPM8 (0.69) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183239-B1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-22 | — | — | EP | disclosed |