Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 5/20 | 0.36 |
| ▸ | TTBK1 | Q5TCY1 | 8/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.34 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12490348 | 0.79 | ROCK1 (0.34) | ROCK1TTBK1MAP3K14TTBK2PAK4 | |
| SCHEMBL12001811 | 0.79 | TTBK1 (0.43) | ROCK1TTBK1MAP3K14TTBK2PAK4 | |
| SCHEMBL11970600 | 0.78 | MAP3K14 (0.47) | ROCK1TTBK1MAP3K14TTBK2CDC7 | |
| SCHEMBL11970869 | 0.77 | PAK4 (0.61) | TTBK1MAP3K14TTBK2PAK4PIKFYVE | |
| SCHEMBL12001576 | 0.73 | TTBK1 (0.38) | TTBK1MAP3K14TTBK2PAK4PIKFYVE | |
| SCHEMBL12490300 | 0.73 | ROCK1 (0.37) | ROCK1TTBK1MAP3K14TTBK2PAK4 | |
| SCHEMBL12490112 | 0.73 | TTBK1 (0.37) | ROCK1TTBK1MAP3K14TTBK2PAK4 | |
| SCHEMBL12490146 | 0.72 | FFAR4 (0.39) | ROCK1TTBK1MAP3K14TTBK2PAK4 | |
| SCHEMBL12490351 | 0.72 | ROCK1 (0.38) | ROCK1TTBK1MAP3K14TTBK2PAK4 | |
| SCHEMBL11970692 | 0.72 | PAK4 (0.48) | TTBK1MAP3K14TTBK2PAK4PIKFYVE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150038460-A1 | 6,5-Heterocyclic Propargylic Alcohol Compounds and Uses Therefor | GENENTECH, INC. (US) | 2015-02-05 | — | — | US | disclosed |
| US-8901313-B2 | 6,5-heterocyclic propargylic alcohol compounds and uses therefor | GENENTECH, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| EP-2686314-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | F.HOFFMANN-LA ROCHE AG (CH) | 2014-01-22 | — | — | EP | disclosed |
| WO-2012123522-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | GENENTECH, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | NFKB1, NFRKB, NFKBIA | ROCK1 1846/4885TTBK1 915/4885MAP3K14 519/4885 |
| US-20150038460-A1 | 6,5-Heterocyclic Propargylic Alcohol Compounds and Uses Therefor | NFKB1, NFRKB, NFKBIA | ROCK1 1846/4885TTBK1 915/4885MAP3K14 519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.