Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | BID | P55957 | 3/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.44 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.44 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.44 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | CTSG | P08311 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetone SCHEMBL27863904 | 0.90 | IAPP (0.50) | IAPPALOX5PTGS2BIDMCL1 | |
| SCHEMBL29558088 | 0.90 | ALOX5 (0.54) | IAPPALOX5PTGS2BIDMCL1 | |
| SCHEMBL21838 | 0.90 | ALOX5 (0.54) | IAPPALOX5PTGS2BIDMCL1 | |
| Acetic Acid SCHEMBL9466871 | 0.89 | BID (0.49) | IAPPALOX5PTGS2BIDMCL1 | |
| Water SCHEMBL27618995 | 0.88 | ALOX5 (0.53) | IAPPALOX5PTGS2BIDMCL1 | |
| SCHEMBL28838335 | 0.88 | ALOX5 (0.53) | IAPPALOX5PTGS2BIDMCL1 | |
| Acetic Acid SCHEMBL28009227 | 0.87 | BID (0.48) | IAPPALOX5PTGS2BIDMCL1 | |
| SCHEMBL28838336 | 0.85 | ALOX5 (0.50) | IAPPALOX5PTGS2BIDMCL1 | |
| SCHEMBL1022161 | 0.84 | ALOX5 (0.62) | IAPPALOX5PTGS2BIDMCL1 | |
| Methacrylic Acid SCHEMBL6535115 | 0.83 | BID (0.44) | IAPPALOX5PTGS2BIDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9254329-B2 | Stable protective coatings for pharmaceutical dosage forms | BASF SE (DE) | 2016-02-09 | — | — | US | disclosed |
| US-20120214917-A1 | Stable Protective Coatings For Pharmaceutical Dosage Forms | BASF SE (DE) | 2012-08-23 | — | — | US | disclosed |