SCHEMBL11977591

SCHEMBL11977591

CC(C)(C)OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCNCc1ccccc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

nearest known ligand 0.61

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ FOLH1 Q04609 13/20 0.61
▸ MEN1 O00255 2/20 0.49
▸ KMT2A Q03164 2/20 0.49
▸ MAPT P10636 1/20 0.49
▸ NPSR1 Q6W5P4 1/20 0.49
▸ PAX8 Q06710 1/20 0.45
▸ TDP1 Q9NUW8 1/20 0.45
▸ CTSK P43235 1/20 0.44
▸ ATM Q13315 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21345164 0.99 FOLH1 (0.60) FOLH1MEN1KMT2AMAPTNPSR1
SCHEMBL12925116 0.96 FOLH1 (0.57) FOLH1MEN1KMT2AMAPTNPSR1
SCHEMBL20089634 0.93 FOLH1 (0.72) FOLH1CTSKATM
SCHEMBL17937433 0.90 FOLH1 (0.61) FOLH1MEN1KMT2AMAPTNPSR1
SCHEMBL30022115 0.90 FOLH1 (0.61) FOLH1MEN1KMT2AMAPTNPSR1
SCHEMBL12925107 0.90 FOLH1 (0.48) FOLH1MEN1KMT2AMAPTNPSR1
SCHEMBL19874793 0.90 FOLH1 (0.61) FOLH1MEN1KMT2AMAPTNPSR1
SCHEMBL1077625 0.88 FOLH1 (0.47) FOLH1MEN1KMT2AMAPTNPSR1
SCHEMBL1077623 0.88 FOLH1 (0.47) FOLH1MEN1KMT2AMAPTNPSR1
SCHEMBL15449633 0.87 FOLH1 (0.46) FOLH1MEN1KMT2AMAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210246103-A1 HETERODIMERS OF GLUTAMIC ACID CITIZENS BANK, N.A. 2021-08-12 — — US disclosed
US-20210070695-A1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHT PHARMACEUTICALS, INC. 2021-03-11 — — US disclosed
US-20210070696-A1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHT PHARMACEUTICALS, INC. 2021-03-11 — — US disclosed
US-10647666-B2 Heterodimers of glutamic acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2020-05-12 — — US disclosed
US-10640461-B2 Heterodimers of glutamic acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2020-05-05 — — US disclosed
US-20190276393-A1 Heterodimers of Glutamic Acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2019-09-12 — — US disclosed
US-20180111895-A1 Heterodimers of Glutamic Acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2018-04-26 — — US disclosed
US-20180111895-A1 Heterodimers of Glutamic Acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2018-04-26 — — US disclosed
US-9878980-B2 Heterodimers of glutamic acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2018-01-30 — — US disclosed
US-9878980-B2 Heterodimers of glutamic acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2018-01-30 — — US disclosed
US-9309193-B2 Heterodimers of glutamic acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2016-04-12 — — US disclosed
US-9309193-B2 Heterodimers of glutamic acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2016-04-12 — — US disclosed
US-8487129-B2 Heterodimers of glutamic acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2013-07-16 — — US disclosed
US-8487129-B2 Heterodimers of glutamic acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. (US) 2013-07-16 — — US disclosed
US-20120269726-A1 Heterodimers of Glutamic Acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. 2012-10-25 — — US disclosed
US-20120269726-A1 Heterodimers of Glutamic Acid MOLECULAR INSIGHT PHARMACEUTICALS, INC. 2012-10-25 — — US disclosed
US-20120208988-A1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHTS PHARMACEUTICALS, INC. (US) 2012-08-16 — — US disclosed
US-20120208988-A1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHTS PHARMACEUTICALS, INC. (US) 2012-08-16 — — US disclosed
US-20080193381-A1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHT PHARMACEUTICALS, INC. 2008-08-14 — — US disclosed
US-20080193381-A1 HETERODIMERS OF GLUTAMIC ACID MOLECULAR INSIGHT PHARMACEUTICALS, INC. 2008-08-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210070695-A1 HETERODIMERS OF GLUTAMIC ACID DDO, GLUL, ASNS FOLH1 5/4885MEN1 2461/4885KMT2A 2413/4885
US-20190276393-A1 Heterodimers of Glutamic Acid GLUL, DDO, ASNS FOLH1 4/4885MEN1 2804/4885KMT2A 2234/4885
US-10647666-B2 Heterodimers of glutamic acid DDO, GLUL, ASNS FOLH1 5/4885MEN1 2461/4885KMT2A 2413/4885
US-20120269726-A1 Heterodimers of Glutamic Acid DDO, GLUL, ASNS FOLH1 5/4885MEN1 2384/4885KMT2A 2428/4885
US-20080193381-A1 HETERODIMERS OF GLUTAMIC ACID DDO, GLUL, ASNS FOLH1 5/4885MEN1 2461/4885KMT2A 2413/4885
US-20210070696-A1 HETERODIMERS OF GLUTAMIC ACID DDO, GLUL, ASNS FOLH1 5/4885MEN1 2472/4885KMT2A 2402/4885
US-20120208988-A1 HETERODIMERS OF GLUTAMIC ACID DDO, GLUL, ASNS FOLH1 5/4885MEN1 2461/4885KMT2A 2413/4885
US-10640461-B2 Heterodimers of glutamic acid DDO, GLUL, ASNS FOLH1 5/4885MEN1 2461/4885KMT2A 2413/4885
US-20210246103-A1 HETERODIMERS OF GLUTAMIC ACID DDO, GLUL, ASNS FOLH1 5/4885MEN1 2461/4885KMT2A 2413/4885
US-20180111895-A1 Heterodimers of Glutamic Acid DDO, GLUL, ASNS FOLH1 5/4885MEN1 2439/4885KMT2A 2466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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