GLUL — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1874784	0.67	4/20
SCHEMBL1877560	0.61	4/20
SCHEMBL1880341	0.68	3/20
SCHEMBL2618327	0.62	3/20
SCHEMBL2631126	0.62	3/20
SCHEMBL1872953	0.60	3/20
SCHEMBL1874783	0.55	3/20
SCHEMBL1142486	0.54	3/20
SCHEMBL1142489	0.54	3/20
SCHEMBL1142492	0.54	3/20
SCHEMBL1142123	0.54	3/20
SCHEMBL1142125	0.54	3/20
SCHEMBL1142456	0.54	3/20
SCHEMBL1142458	0.54	3/20
SCHEMBL1142460	0.54	3/20
SCHEMBL1142457	0.51	3/20
SCHEMBL1142461	0.51	3/20
SCHEMBL1141808	0.51	3/20
SCHEMBL1141812	0.51	3/20
SCHEMBL2502438	0.51	3/20

Clinical trials — most relevant to GLUL by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
L-ornithine L-aspartate in Overt Hepatic Encephalopathy	PHASE4	COMPLETED
Relationship Between Efficacy of Lumateperone and Brain Glutamate and Dopamine	PHASE4	WITHDRAWN
Glutamate for Metabolic Intervention in Coronary Surgery	PHASE3	COMPLETED
Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure	PHASE2	UNKNOWN
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders	PHASE2	COMPLETED
Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial	PHASE2	COMPLETED
Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange Syndrome	PHASE2	NOT_YET_RECRUITING
Anaplerotic Therapy in Propionic Acidemia	PHASE1	COMPLETED
Glutamine and Traumatic Brain Injury	EARLY_PHASE1	UNKNOWN
Glutamine Supplementation in People With Immune Dysregulation	EARLY_PHASE1	WITHDRAWN
Ketamine Infusion for Social Anxiety Disorder	EARLY_PHASE1	COMPLETED
Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine	EARLY_PHASE1	COMPLETED
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 2: 7T MRI	nan	COMPLETED
High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions	nan	COMPLETED
Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers	nan	COMPLETED
Oncometabolome and MALDI-MSI in Upper GI Carcinomas - Chemosensitivity in Esophageal Carcinoma	nan	ACTIVE_NOT_RECRUITING
Cognitive Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder	nan	COMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
Study of Glutamate and Glutamine Metabolism in Burn Patients Receiving Enteral or Parenteral Nutrition	nan	WITHDRAWN
Urinary Steroid Metabolites in Autism	nan	UNKNOWN
Glutamine Enriched Total Parenteral Feeding and Proline Metabolism in Severely Burned Patients	nan	WITHDRAWN
Efficacy of Glutamine in Management of Radiation Mucositis	nan	UNKNOWN
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)	nan	UNKNOWN
Glutamate Supplementation in Young Men	nan	COMPLETED
Effect of Glutamine Supplemented Nutrition Support on Protein and Glutamine Metabolism in Burns	nan	WITHDRAWN
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 1: Simultaneous PET and 3T MRI	nan	COMPLETED
1H Magnetic Resonance Spectroscopy in Migraine Patients	nan	COMPLETED
Acute Glycine Pharmacodynamic Study	nan	COMPLETED
Glutamate Probes in Adolescent Depression	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GLUL binder may also engage these)

Protein	Name	Similarity
P15105	—	1.000	P15105 →
P15103	—	1.000	P15103 →
P09606	—	1.000	P09606 →
Q8HZM5	—	1.000	Q8HZM5 →
Q9QY94	—	1.000	Q9QY94 →
Q6B4U7	—	1.000	Q6B4U7 →
P16580	—	1.000	P16580 →
P46410	—	0.999	P46410 →
Q6FMT6	—	0.999	Q6FMT6 →
P04773	—	0.999	P04773 →
P51121	—	0.998	P51121 →
P38562	—	0.997	P38562 →
Q4R7U3	—	0.997	Q4R7U3 →
Q42688	—	0.996	Q42688 →
Q06378	—	0.995	Q06378 →
Q09179	—	0.995	Q09179 →
P0CN84	—	0.995	P0CN84 →
O00088	—	0.995	O00088 →
P20478	—	0.995	P20478 →
P51119	—	0.995	P51119 →
O82560	—	0.995	O82560 →
P14654	—	0.994	P14654 →
Q9C2U9	—	0.994	Q9C2U9 →
P38559	—	0.994	P38559 →
Q43785	—	0.994	Q43785 →
Q6C3E0	—	0.994	Q6C3E0 →
P0CN85	—	0.994	P0CN85 →
P32288	—	0.994	P32288 →
P00965	—	0.993	P00965 →
P51118	—	0.993	P51118 →