Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 18/20 | 0.51 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CALCA | P06881 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1197770 | 0.83 | CALCRL (0.56) | CALCRLRAMP1CALCA | |
| SCHEMBL1197428 | 0.81 | CALCRL (0.47) | CALCRLRAMP1 | |
| SCHEMBL1196576 | 0.81 | CALCRL (0.47) | CALCRL | |
| SCHEMBL2899062 | 0.81 | CALCRL (0.65) | CALCRLRAMP1CALCA | |
| SCHEMBL1198359 | 0.80 | CALCRL (0.41) | CALCRL | |
| SCHEMBL1198426 | 0.80 | CALCRL (0.48) | CALCRL | |
| SCHEMBL1197925 | 0.79 | CALCRL (0.54) | CALCRLRAMP1P2RX7CALCAMEN1 | |
| SCHEMBL1197782 | 0.78 | CALCRL (0.38) | CALCRLRAMP1CALCA | |
| SCHEMBL3697359 | 0.76 | CALCRL (0.52) | CALCRLRAMP1CALCA | |
| SCHEMBL3705520 | 0.76 | CALCRL (0.52) | CALCRLRAMP1CALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893052-B2 | CGRP receptor antagonists | MERCK SHARP & DOHME LLC | 2011-02-22 | — | — | US | disclosed |