Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15975104 | 0.90 | GRM4 (0.38) | GRM4MTNR1AMTNR1BPDE5AHDAC11 | |
| SCHEMBL15975098 | 0.88 | GRM4 (0.36) | GRM4MTNR1AMTNR1BPDE5AHDAC11 | |
| SCHEMBL11979679 | 0.88 | PTGS2 (0.43) | PDE5AHDAC11HDAC8 | |
| SCHEMBL11978909 | 0.87 | MCL1 (0.36) | GRM4MTNR1AMTNR1B | |
| SCHEMBL4568480 | 0.85 | MRGPRX4 (0.42) | GRM4MTNR1AMTNR1B | |
| SCHEMBL3707630 | 0.84 | MRGPRX4 (0.43) | PTGER1 | |
| SCHEMBL15975111 | 0.84 | GRM4 (0.38) | GRM4MTNR1AMTNR1BPDE5AHDAC11 | |
| SCHEMBL11978666 | 0.83 | MAP2 (0.39) | GRM4MTNR1AMTNR1BPTGER1 | |
| SCHEMBL4568481 | 0.79 | MRGPRX4 (0.40) | GRM4MTNR1AMTNR1BPDE5AHDAC11 | |
| SCHEMBL4568590 | 0.78 | MRGPRX4 (0.41) | PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| WO-2012102255-A1 | INDOLE DERIVATIVE AND PHARMACOLOGICALLY ACCEPTABLE SALT OF SAME | キッセイ薬品工業株式会社 (JP) | 2012-08-02 | — | — | WO | disclosed |