SCHEMBL11986170

SCHEMBL11986170

C=C(C)C(=O)OCOc1ccc(C(=O)Oc2ccc(C#N)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.50
ALDH1A1 P00352 2/20 0.50
TDP1 Q9NUW8 2/20 0.45
POLB P06746 2/20 0.45
APEX1 P27695 1/20 0.45
HTT P42858 1/20 0.45
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
HIF1A Q16665 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
RAB9A P51151 1/20 0.42
KMT2A Q03164 1/20 0.42
PRSS1 P07477 1/20 0.42
ACR P10323 1/20 0.42
ELANE P08246 1/20 0.41
LMNA P02545 1/20 0.41
TP53 P04637 1/20 0.41
F2 P00734 1/20 0.40
ADRB2 P07550 1/20 0.40
ADRB1 P08588 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16425295 0.96 MAPT (0.47) MAPTALDH1A1TDP1POLBAPEX1
SCHEMBL13289583 0.96 MAPT (0.47) MAPTALDH1A1TDP1POLBAPEX1
SCHEMBL12242713 0.91 POLB (0.52) MAPTALDH1A1TDP1POLBAPEX1
SCHEMBL11986102 0.91 POLB (0.52) MAPTALDH1A1TDP1POLBAPEX1
SCHEMBL13664636 0.90 POLB (0.51) MAPTALDH1A1TDP1POLBAPEX1
SCHEMBL12733727 0.88 ELANE (0.52) MAPTALDH1A1TDP1POLBAPEX1
SCHEMBL12242656 0.87 TDP1 (0.49) MAPTTDP1POLBAPEX1HTT
SCHEMBL12242788 0.87 TDP1 (0.49) MAPTTDP1POLBAPEX1HTT
SCHEMBL19757164 0.87 POLB (0.49) MAPTALDH1A1TDP1POLBAPEX1
SCHEMBL12242616 0.87 TDP1 (0.49) MAPTTDP1POLBAPEX1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9505980-B2 Polymerizable liquid crystal composition and optically anisotropic substance having twist alignment JNC CORPORATION (JP) 2016-11-29 US disclosed
US-9399736-B2 Optically anisotropic substance and liquid crystal display JNC CORPORATION (JP) 2016-07-26 US disclosed
US-9315728-B2 Polymerizable liquid crystal composition and homogeneous-aligned liquid crystal film JNC CORPORATION (JP) 2016-04-19 US disclosed
US-20160011349-A1 INFRARED REFLECTING FILM AND LAMINATED FILM JNC PETROCHEMICAL CORPORATION (JP) 2016-01-14 US disclosed
US-20150146156-A1 OPTICALLY ANISOTROPIC SUBSTANCE AND LIQUID CRYSTAL DISPLAY JNC CORPORATION (JP) 2015-05-28 US disclosed
US-20150108401-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOSITION AND OPTICALLY ANISOTROPIC SUBSTANCE HAVING TWIST ALIGNMENT JNC CORPORATION (JP) 2015-04-23 US disclosed
US-8419973-B2 Polymerizable liquid crystal composition and homeotropically-aligned liquid crystal film JNC CORPORATION (JP) 2013-04-16 US disclosed
US-8246855-B2 Polymerizable liquid crystal composition and optically anisotropic film using the same JNC CORPORATION (JP) 2012-08-21 US disclosed
US-7931825-B2 Polymerizable composition ADEKA CORPORATION (JP) 2011-04-26 US disclosed
US-20100151154-A1 Polymerizable liquid crystal composition and homeotropically-aligned liquid crystal film CHISSO CORPORATION 2010-06-17 US disclosed
US-20100143612-A1 Polymerizable liquid crystal composition and homogeneous-aligned liquid crystal film CHISSO CORPORATION 2010-06-10 US disclosed
US-20100090163-A1 POLYMERIZABLE COMPOSITION ADEKA CORPORATION (JP) 2010-04-15 US disclosed
US-20100051866-A1 Polymerizable liquid crystal composition and optically anisotropic film using the same JNC PETROCHEMICAL CORPORATION (JP) 2010-03-04 US disclosed