Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.31 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.31 |
| ▸ | PIK3R3 | Q92569 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198506 | 0.88 | PDE7A (0.41) | PDE7APDE10APDE3ARAD52PIK3CD | |
| SCHEMBL12874898 | 0.87 | CCNA2 (0.41) | PDE7APDE10APDE3ARAD52PIK3CD | |
| SCHEMBL1199255 | 0.87 | PDE7A (0.40) | PDE7APDE10APDE3ARAD52PIK3CD | |
| SCHEMBL12046652 | 0.86 | PDE7A (0.41) | PDE7APDE10APDE3ARAD52PIK3CD | |
| SCHEMBL1198377 | 0.86 | CCNA2 (0.41) | PDE7APDE10APDE3ARAD52PIK3CD | |
| SCHEMBL1199721 | 0.84 | PDE7A (0.39) | PDE7APDE10APDE3ARAD52PIK3CD | |
| SCHEMBL1199365 | 0.84 | PDE7A (0.41) | PDE7APDE10APDE3ARAD52CCNA2 | |
| SCHEMBL1199426 | 0.84 | PDE7A (0.39) | PDE7APDE10APDE3AMEN1KMT2A | |
| SCHEMBL1199686 | 0.83 | PDE10A (0.42) | PDE7APDE10APDE3ARAD52PIK3CD | |
| SCHEMBL1199219 | 0.83 | PDE7A (0.42) | PDE7APDE10APDE3ARAD52CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459551-B1 | DIHYDROBENZOINDAZOLES | MERCK SHARP & DOHME (NL) | 2014-07-02 | — | — | EP | disclosed |
| US-8071589-B2 | Dihydrobenzoindazoles | N. V. ORGANON (NL) | 2011-12-06 | — | — | US | disclosed |
| US-20110028451-A1 | Dihydrobenzoindazoles | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028451-A1 | Dihydrobenzoindazoles | DHODH, BRDT, HSD17B11 | PDE7A 2158/4885PDE10A 2445/4885PDE3A 931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.