Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 11/20 | 0.53 |
| ▸ | PPARG | P37231 | 10/20 | 0.53 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967738 | 0.90 | PPARG (0.62) | PPARAPPARGPTPN1SLC6A9SLC6A2 | |
| SCHEMBL3971738 | 0.89 | PPARA (0.52) | PPARAPPARGPPARDPTPN1SLC6A9 | |
| SCHEMBL3973894 | 0.89 | PPARA (0.52) | PPARAPPARGPPARDPTPN1SLC6A9 | |
| SCHEMBL3971145 | 0.89 | PPARA (0.52) | PPARAPPARGPPARDPTPN1SLC6A9 | |
| SCHEMBL11993139 | 0.87 | PPARA (0.42) | PPARAPPARGPPARDPTPN1KIF11 | |
| Pemaglitazar SCHEMBL6902218 | 0.81 | PPARA (0.52) | PPARAPPARGPPARDPTPN1SLC6A9 | |
| Pemaglitazar SCHEMBL6902223 | 0.81 | PPARA (0.52) | PPARAPPARGPPARDPTPN1SLC6A9 | |
| SCHEMBL3973311 | 0.81 | PPARG (0.54) | PPARAPPARGPTPN1 | |
| SCHEMBL3976202 | 0.81 | PPARG (0.51) | PPARAPPARGPPARDPTPN1SLC6A9 | |
| SCHEMBL11993021 | 0.81 | PPARG (0.51) | PPARAPPARGPPARDPTPN1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412326-B1 | BUTYRIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-08-22 | — | — | EP | disclosed |
| US-7491747-B2 | 4-(Arylthio)- or (4-heteroarylthio)butyric acid derivatives that may be used in the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2009-02-17 | — | — | US | disclosed |
| US-7491747-B2 | 4-(Arylthio)- or (4-heteroarylthio)butyric acid derivatives that may be used in the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2009-02-17 | — | — | US | disclosed |