Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 11/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.38 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12012940 | 0.94 | MAPK14 (0.41) | MAPK14FGFR4CSNK2A2CSNK2A1HIPK2 | |
| SCHEMBL3310314 | 0.94 | KCNH2 (0.44) | MAPK14FGFR4CSNK2A2CSNK2A1HIPK2 | |
| SCHEMBL3313469 | 0.87 | CSNK2A2 (0.42) | FGFR4CSNK2A2CSNK2A1TYK2 | |
| SCHEMBL3311369 | 0.86 | TYK2 (0.40) | MAPK14FGFR4CSNK2A2TYK2 | |
| SCHEMBL3311742 | 0.84 | CSNK2A1 (0.46) | MAPK14CSNK2A2CSNK2A1HIPK2HIPK1 | |
| SCHEMBL13644218 | 0.82 | CSNK2A2 (0.41) | FGFR4CSNK2A2TYK2 | |
| SCHEMBL3309971 | 0.82 | CSNK2A2 (0.42) | MAPK14CSNK2A2CSNK2A1HIPK2HIPK1 | |
| SCHEMBL3313776 | 0.82 | CSNK2A2 (0.53) | CSNK2A2CSNK2A1HIPK2HIPK1DYRK2 | |
| SCHEMBL13421552 | 0.81 | MAPK14 (0.42) | MAPK14TYK2 | |
| SCHEMBL13421530 | 0.81 | TYK2 (0.41) | MAPK14CSNK2A2CSNK2A1HIPK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252795-B2 | Imidazopyridazinecarbonitriles useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-28 | — | — | US | claimed |