Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13421552 | 0.93 | MAPK14 (0.42) | TYK2MAPK14KDRPDE4D | |
| SCHEMBL3310314 | 0.87 | KCNH2 (0.44) | TYK2MAPK14KCNH2DYRK3CSNK2A2 | |
| SCHEMBL13421386 | 0.86 | TYK2 (0.39) | TYK2CSNK2A2CDK2PDE4D | |
| SCHEMBL13422030 | 0.86 | TYK2 (0.42) | TYK2MAPK14KCNH2DYRK3CSNK2A2 | |
| SCHEMBL13422028 | 0.83 | MAPK14 (0.41) | TYK2MAPK14KCNH2DYRK3CSNK2A2 | |
| SCHEMBL13421572 | 0.83 | KCNH2 (0.44) | TYK2MAPK14KCNH2DYRK3CSNK2A2 | |
| SCHEMBL13421481 | 0.81 | TYK2 (0.55) | TYK2KCNH2DYRK3CSNK2A2CDK2 | |
| SCHEMBL11996471 | 0.81 | MAPK14 (0.40) | TYK2MAPK14KCNH2DYRK3CSNK2A2 | |
| SCHEMBL13421587 | 0.81 | KCNH2 (0.37) | TYK2MAPK14KCNH2DYRK3CSNK2A2 | |
| SCHEMBL13421762 | 0.80 | CDK2 (0.40) | TYK2MAPK14KCNH2DYRK3CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042699-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |