Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.83 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.64 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14648444 | 0.95 | DPP4 (0.92) | DPP4DPP8DPP9PIK3CAKDM4C | |
| SCHEMBL163502 | 0.91 | DPP4 (1.00) | DPP4DPP8DPP9PIK3CA | |
| SCHEMBL2555136 | 0.91 | DPP4 (1.00) | DPP4DPP8DPP9PIK3CA | |
| SCHEMBL882339 | 0.91 | DPP4 (0.81) | DPP4DPP8DPP9PIK3CAKDM4C | |
| SCHEMBL20162036 | 0.91 | DPP4 (1.00) | DPP4DPP8DPP9PIK3CA | |
| SCHEMBL646974 | 0.91 | DPP4 (1.00) | DPP4DPP8DPP9PIK3CA | |
| SCHEMBL1040802 | 0.91 | DPP4 (1.00) | DPP4DPP8DPP9PIK3CA | |
| SCHEMBL11997944 | 0.88 | DPP4 (0.65) | DPP4DPP8DPP9PDK1PDK2 | |
| SCHEMBL13287073 | 0.86 | DPP4 (0.92) | DPP4DPP8DPP9PIK3CA | |
| SCHEMBL18175266 | 0.86 | DPP4 (0.92) | DPP4DPP8DPP9PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057145-B1 | SYNTHESIS OF (2S,5R)-5-ETHYNYL-1-{N-(4-METHYL-1-(4-CARBOXY-PYRIDIN-2-YL)PIPERIDIN-4-YL)GLYCYL}PYRROLIDINE-2-CARBONITRILE | ABBOTT LAB (US) | 2012-08-22 | — | — | EP | disclosed |