Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 16/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12001585 | 0.85 | MAP3K14 (0.46) | MAP3K14ROCK1TTBK1 | |
| SCHEMBL11971037 | 0.81 | TTBK1 (0.73) | MAP3K14ROCK1TTBK1 | |
| SCHEMBL12525986 | 0.80 | MAP3K14 (0.63) | MAP3K14ROCK1 | |
| SCHEMBL11970906 | 0.79 | MAP3K14 (0.59) | MAP3K14ROCK1CDC7CDK2 | |
| SCHEMBL12001694 | 0.77 | MAP3K14 (0.57) | MAP3K14ROCK1CDC7CDK2 | |
| SCHEMBL12001651 | 0.77 | MAP3K14 (0.60) | MAP3K14ROCK1CDC7CDK2 | |
| SCHEMBL12001695 | 0.77 | MAP3K14 (0.59) | MAP3K14ROCK1CDC7CDK2 | |
| SCHEMBL11970723 | 0.75 | MAP3K14 (0.58) | MAP3K14TTBK1 | |
| SCHEMBL11970709 | 0.73 | MAP3K14 (0.66) | MAP3K14TTBK1 | |
| SCHEMBL11970820 | 0.72 | MAP3K14 (0.61) | MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012123522-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | GENENTECH, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | NFKB1, NFRKB, NFKBIA | MAP3K14 519/4885ROCK1 1846/4885TTBK1 915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.