Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 9/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.33 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12001596 | 0.93 | TTBK1 (0.38) | CDC7CDK2TTBK1PAK4PIKFYVE | |
| SCHEMBL12001572 | 0.89 | TTBK1 (0.39) | CDC7CDK2TTBK1PAK4PIKFYVE | |
| SCHEMBL12001709 | 0.87 | TTBK1 (0.38) | CDC7CDK2TTBK1PAK4PIKFYVE | |
| SCHEMBL12001606 | 0.86 | TTBK1 (0.38) | CDC7CDK2TTBK1PAK4PIKFYVE | |
| SCHEMBL12001723 | 0.85 | MAP3K14 (0.39) | CDC7CDK2TTBK1PAK4PIKFYVE | |
| SCHEMBL11970721 | 0.84 | PAK4 (0.47) | TTBK1PAK4PIKFYVEMAP3K14 | |
| SCHEMBL12001522 | 0.83 | TTBK1 (0.35) | CDC7CDK2TTBK1PAK4PIKFYVE | |
| SCHEMBL12001566 | 0.83 | TTBK1 (0.35) | CDC7CDK2TTBK1PAK4PIKFYVE | |
| SCHEMBL12001714 | 0.83 | MAP3K14 (0.37) | CDC7CDK2TTBK1PAK4PIKFYVE | |
| SCHEMBL12001730 | 0.81 | TTBK1 (0.36) | CDC7CDK2TTBK1PAK4PIKFYVE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | GENENTECH, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | NFKB1, NFRKB, NFKBIA | CDC7 4283/4885CDK2 2025/4885TTBK1 915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.