Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 4/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12001556 | 1.00 | MAP3K14 (0.42) | MAP3K14KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL12001559 | 1.00 | MAP3K14 (0.42) | MAP3K14KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL11970986 | 0.86 | MAP3K14 (0.58) | MAP3K14GRM5 | |
| SCHEMBL11971143 | 0.86 | MAP3K14 (0.58) | MAP3K14GRM5 | |
| SCHEMBL11970884 | 0.86 | MAP3K14 (0.58) | MAP3K14GRM5 | |
| SCHEMBL12001524 | 0.82 | PIK3CD (0.35) | MAP3K14KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL11970664 | 0.80 | MAPT (0.40) | KDM4EALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL12001623 | 0.80 | MAP3K14 (0.38) | MAP3K14ROCK1 | |
| SCHEMBL11970555 | 0.78 | DYRK3 (0.50) | MAP3K14KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL12001653 | 0.75 | TTBK1 (0.38) | KDM4EALDH1A1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | GENENTECH, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | NFKB1, NFRKB, NFKBIA | MAP3K14 519/4885KDM4E 3644/4885ALDH1A1 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.