Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12005260 | 1.00 | EPHX2 (0.46) | EPHX2DEGS1NPC1ALDH1A1RAB9A | |
| SCHEMBL6863167 | 1.00 | EPHX2 (0.46) | EPHX2DEGS1NPC1ALDH1A1RAB9A | |
| SCHEMBL6862768 | 0.87 | USP30 (0.58) | EPHX2NPC1RAB9ASMN1; SMN2USP30 | |
| SCHEMBL12004494 | 0.87 | USP30 (0.58) | EPHX2NPC1RAB9ASMN1; SMN2USP30 | |
| SCHEMBL12004497 | 0.87 | USP30 (0.58) | EPHX2NPC1RAB9ASMN1; SMN2USP30 | |
| SCHEMBL6862613 | 0.83 | KCNH2 (0.43) | EPHX2DEGS1USP30NAMPT | |
| SCHEMBL12006299 | 0.83 | KCNH2 (0.43) | EPHX2DEGS1USP30NAMPT | |
| SCHEMBL12006298 | 0.83 | KCNH2 (0.43) | EPHX2DEGS1USP30NAMPT | |
| SCHEMBL6863159 | 0.82 | EPHX2 (0.46) | EPHX2ALDH1A1NAMPT | |
| SCHEMBL6863439 | 0.82 | EPHX2 (0.46) | EPHX2ALDH1A1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | CACNA1G, CACNA1I, CACNA1H | EPHX2 3610/4885DEGS1 324/4885NPC1 910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.