Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL601643 | 0.83 | TSHR (0.59) | TSHRTP53LMNAF2ALDH1A1 | |
| SCHEMBL23777037 | 0.83 | TSHR (0.59) | TSHRTP53LMNAF2ALDH1A1 | |
| SCHEMBL12977332 | 0.81 | TSHR (0.57) | TSHRTP53LMNAF2ALDH1A1 | |
| SCHEMBL27926613 | 0.81 | TSHR (0.57) | TSHRTP53LMNAF2ALDH1A1 | |
| SCHEMBL11474021 | 0.81 | TSHR (0.57) | TSHRTP53LMNAF2ALDH1A1 | |
| SCHEMBL4445835 | 0.81 | TSHR (0.57) | TSHRTP53LMNAF2ALDH1A1 | |
| SCHEMBL9615408 | 0.79 | TSHR (0.55) | TSHRTP53LMNAF2ALDH1A1 | |
| SCHEMBL28024698 | 0.79 | TSHR (0.55) | TSHRTP53LMNAF2ALDH1A1 | |
| SCHEMBL27926927 | 0.79 | TSHR (0.55) | TSHRTP53LMNAF2ALDH1A1 | |
| SCHEMBL11505949 | 0.79 | TSHR (0.55) | TSHRTP53LMNAF2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109804306-A | Light orientation copolymer material | 罗利克技术有限公司 | 2019-05-24 | — | — | CN | disclosed |
| CN-108350174-A | Photo-alignment material | 罗利克技术有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-108350363-A | Can photo-alignment material composition | 罗利克技术有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-105051023-B | Stem cell is promoted to be divided into the compound of liver cell | 豪夫迈·罗氏有限公司 | 2017-08-22 | — | — | CN | disclosed |
| CN-105051023-A | Compounds for improved stem cell differentiation into hepatocytes | HOFFMANN LA ROCHE | 2015-11-11 | — | — | CN | disclosed |
| US-8946259-B2 | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140066477-A1 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2014-03-06 | — | — | US | disclosed |
| US-8598353-B2 | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-12-03 | — | — | US | disclosed |
| EP-1863771-B1 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2012-11-07 | — | — | EP | disclosed |
| CN-101142194-B | Benzazole derivatives, compositions, and methods of use as b-secretase inhibitors | TRANSTECH PHARMA INC | 2012-10-10 | — | — | CN | disclosed |
| US-20110065713-A1 | Benzazole Derivatives, Compositions, and Methods of Use as B-Secretase Inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-03-17 | — | — | US | disclosed |
| US-7893267-B2 | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090326006-A1 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors | VTVX HOLDINGS II LLC | 2009-12-31 | — | — | US | disclosed |
| EP-1863771-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | Transtech Pharma, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| US-20060223849-A1 | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC | 2006-10-05 | — | — | US | disclosed |
| WO-2006099379-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2006-09-21 | — | — | WO | disclosed |
| EP-1196398-A4 | BRIDGED FLUORESCENT DYES, THEIR PREPARATION AND THEIR USE IN ASSAYS | SURROMED INC (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6403807-B1 | CYANINE DYES HAVING SEPARATE SECOND LINKING CHAIN JOINING TWO HETEROCYCLES TO RESTRAIN COMPOUND INTO DESIRED CONFORMATION WHICH ABSORBS ELECTROMAGNETIC ENERGY AND EMITS FLUORESCENCE AT SPECIFIED WAVELENGTHS | SURROMED, INC. | 2002-06-11 | — | — | US | disclosed |
| EP-1196398-A1 | BRIDGED FLUORESCENT DYES, THEIR PREPARATION AND THEIR USE IN ASSAYS | Surromed, Inc. (US) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001002374-A1 | BRIDGED FLUORESCENT DYES, THEIR PREPARATION AND THEIR USE IN ASSAYS | SURROMED, INC. (US) | 2001-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326006-A1 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors | BACE1, BACE2, APP | TSHR 4866/4885TP53 2464/4885LMNA 679/4885 |
| US-20110065713-A1 | Benzazole Derivatives, Compositions, and Methods of Use as B-Secretase Inhibitors | BACE1, BACE2, APP | TSHR 4862/4885TP53 2358/4885LMNA 457/4885 |
| US-20060223849-A1 | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors | BACE1, BACE2, APP | TSHR 4866/4885TP53 2464/4885LMNA 679/4885 |
| US-20140066477-A1 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors | BACE1, BACE2, APP | TSHR 4866/4885TP53 2464/4885LMNA 679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.