Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 10/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.60 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | TCF4 | P15884 | 1/20 | 0.59 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12009085 | 0.94 | TCF4 (0.67) | S1PR4NPC1RAB9AS1PR1S1PR5 | |
| SCHEMBL12009028 | 0.92 | S1PR4 (0.58) | S1PR4NPC1RAB9AS1PR1S1PR5 | |
| SCHEMBL18545612 | 0.87 | TCF4 (0.73) | S1PR4NPC1RAB9AS1PR1S1PR5 | |
| SCHEMBL12009073 | 0.87 | TCF4 (0.73) | S1PR4NPC1RAB9AS1PR1S1PR5 | |
| SCHEMBL12009715 | 0.86 | TCF4 (0.65) | S1PR4NPC1RAB9AS1PR1S1PR5 | |
| SCHEMBL12009730 | 0.85 | TCF4 (0.56) | S1PR4NPC1RAB9AS1PR1S1PR5 | |
| SCHEMBL18545578 | 0.84 | TCF4 (0.66) | S1PR4NPC1RAB9AS1PR1S1PR5 | |
| SCHEMBL12009037 | 0.84 | TCF4 (0.66) | S1PR4NPC1RAB9AS1PR1S1PR5 | |
| SCHEMBL18545581 | 0.84 | TCF4 (0.61) | S1PR4NPC1RAB9AS1PR1S1PR5 | |
| SCHEMBL13464591 | 0.84 | TCF4 (0.61) | S1PR4NPC1RAB9AS1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252823-B2 | Oxazole and thiazole compounds as beta-catenin modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2012-08-28 | — | — | US | disclosed |
| US-20090227624-A1 | Oxazole and thiazole compounds as beta-catenin modulators and uses thereof | US ARMY, SECRETARY OF THE ARMY | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227624-A1 | Oxazole and thiazole compounds as beta-catenin modulators and uses thereof | CTNNB1, CTNNA1, CTNNBL1 | S1PR4 3613/4885NPC1 1604/4885RAB9A 3367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.