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TCF4

Transcription factor 4 (TCF-4) (Class B basic · P15884 · TCF4 on Sugi Atlas →

10,007 patent compounds predicted against TCF4, 6,526 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Cercosporin Cercosporin (SCHEMBL498747) 0.71 5/20
SCHEMBL1591981 SCHEMBL1591981 1.00 3/20
SCHEMBL1559610 SCHEMBL1559610 0.89 3/20
SCHEMBL1591810 SCHEMBL1591810 0.83 3/20
SCHEMBL749276 SCHEMBL749276 0.77 3/20
SCHEMBL1560092 SCHEMBL1560092 0.74 3/20
SCHEMBL748379 SCHEMBL748379 0.63 3/20
SCHEMBL749259 SCHEMBL749259 0.60 3/20
SCHEMBL749663 SCHEMBL749663 0.50 3/20
SCHEMBL748301 SCHEMBL748301 0.47 3/20
SCHEMBL1592280 SCHEMBL1592280 0.83 2/20
SCHEMBL1591993 SCHEMBL1591993 0.79 2/20
SCHEMBL1592045 SCHEMBL1592045 0.73 2/20
SCHEMBL1591853 SCHEMBL1591853 0.71 2/20
SCHEMBL1592189 SCHEMBL1592189 0.69 2/20
SCHEMBL749907 SCHEMBL749907 0.68 2/20
SCHEMBL1591177 SCHEMBL1591177 0.67 2/20
SCHEMBL748363 SCHEMBL748363 0.66 2/20
SCHEMBL1591567 SCHEMBL1591567 0.65 2/20
SCHEMBL787878 SCHEMBL787878 0.65 2/20

Clinical trials — most relevant to TCF4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes PHASE4UNKNOWN
Mechanisms of Lipodystrophy in HIV-Infected Pateints PHASE4COMPLETED
The Effect of rs7903146 Genotype on Islet GLP-1 Production in Humans PHASE2NOT_YET_RECRUITING
9-ING-41 in Patients With Advanced Cancers PHASE2ACTIVE_NOT_RECRUITING
Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma PHASE1COMPLETED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC) PHASE1COMPLETED
Can Gluten-free Diet Prevent the Destruction of Beta-cells During Remission? EARLY_PHASE1UNKNOWN
A Clinical Trial Evaluating the Safety and Efficacy of Intravenous CD-801 in Treating Advanced HCC Patients EARLY_PHASE1RECRUITING
A Clinical Trial for the Safety and Efficacy of CD-801 in Patients With Advanced Hepatocellular Carcinoma EARLY_PHASE1COMPLETED
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome nanCOMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
A Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 Polymorphisms nanCOMPLETED
Observational Study to Assess Glycosylated Hemoglobin Changes After 6 Months of Treatment With Pioglitazone. nanCOMPLETED
The Role of Regulatory T Cell in Patients With Type 1 Diabetes Mellitus nanUNKNOWN
LEF1 EXPRESSION IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: A MARKER FOR DIAGNOSIS AND SURVIVAL PREDICTION nanRECRUITING
RORC Genetic Polymorphism of Rheumatoid Arthritis nanCOMPLETED
Pharmacogenetic Profiling of Antipsychotics-Induced X-Syndrome and Diabetes (PAXD) nanUNKNOWN
Identification of Viable Human Embryos Using Three Different Methods nanCOMPLETED
Study to Investigate Adipocyte Cell and Lipid Turnover in Obese Adolescents nanCOMPLETED
Epithelial Mesenchymal Transition and Periodontitis nanUNKNOWN
The Role of TBX3 in Human ES Cell Differentiation nanWITHDRAWN
Peripheral Blood Stem Cells Obtained From Normal Volunteers for Studying Retroviral Vector Mediated Gene Transfer Into Primitive Hematopoietic Cells and Vector Mediated Transgene Expression in Mature Hematopoietic Lineages nanCOMPLETED
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes nanACTIVE_NOT_RECRUITING
Tissue Expression of Krüppel-Like Factors 4 and 7 in Bone Tumors nanRECRUITING
Patient Specific Induced Pluripotency Stem Cells (PSiPS) nanCOMPLETED
Epigenomic Profiling of Circulating Cell-Free DNA (cfDNA) to Characterize the Dynamic Evolution of Molecular Subtypes in Extensive-Stage Small Cell Lung Cancer During First-Line Chemoimmunotherapy nanNOT_YET_RECRUITING
Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study) nanCOMPLETED
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study nanCOMPLETED
Uterine Cavity Assessment and Endometrial Gene Expression in Tamoxifen Treated Breast Cancer Patients nanUNKNOWN
Effect of Different Therapeutic Strategies on Regulatory T Cells in Kidney Transplantation nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TCF4 binder may also engage these)

ProteinNameSimilarity
Q60722 — 1.000 Q60722 →
P51514 — 1.000 P51514 →
P15881 — 1.000 P15881 →
Q61286 — 1.000 Q61286 →
Q62655 — 1.000 Q62655 →
A0A0R4IBL7 — 1.000 A0A0R4IBL7 →
TCF12 Transcription factor 12 0.999 landscape →
P98180 — 0.997 P98180 →
Q01978 — 0.997 Q01978 →
P30985 — 0.997 P30985 →
P15923 — 0.996 P15923 →
Q60420 — 0.994 Q60420 →
P21677 — 0.994 P21677 →
P15806 — 0.990 P15806 →
O09000 — 0.983 O09000 →
Q9NRA8 — 0.977 Q9NRA8 →
Q91VX2 — 0.977 Q91VX2 →
Q7T2G1 — 0.977 Q7T2G1 →
Q8WXX7 — 0.976 Q8WXX7 →
O57539 — 0.976 O57539 →
P70365 — 0.976 P70365 →
NCOA3 Nuclear receptor coactivator 3 0.976 landscape →
NCOA1 Nuclear receptor coactivator 1 0.975 landscape →
UBAP2 Ubiquitin-associated protein 2 0.975 landscape →
A0A087WPF7 — 0.975 A0A087WPF7 →
Q9EPU2 — 0.974 Q9EPU2 →
Q4PJW2 — 0.974 Q4PJW2 →
UBAP2L Ubiquitin-associated protein 2-like 0.973 landscape →
Q80TM6 — 0.973 Q80TM6 →
Q9Y2K5 — 0.973 Q9Y2K5 →