Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.56 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.51 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12952076 | 1.00 | ADORA2A (0.63) | ADORA2AADORA3ADORA2BADORA1HSP90B1 | |
| SCHEMBL12952377 | 0.98 | ADORA2A (0.63) | ADORA2AADORA3ADORA2BADORA1HSP90B1 | |
| SCHEMBL12952375 | 0.97 | ADORA2A (0.65) | ADORA2AADORA3ADORA2BADORA1HSP90B1 | |
| SCHEMBL12010007 | 0.94 | ADORA2A (0.62) | ADORA2AADORA3ADORA2BADORA1HSP90B1 | |
| SCHEMBL12927110 | 0.93 | ADORA2A (0.60) | ADORA2AADORA3ADORA2BADORA1HSP90B1 | |
| SCHEMBL12009347 | 0.93 | ADORA2A (0.60) | ADORA2AADORA3ADORA2BADORA1HSP90B1 | |
| SCHEMBL12153352 | 0.93 | ADORA2A (0.62) | ADORA2AADORA3ADORA2BADORA1HSP90B1 | |
| SCHEMBL12009927 | 0.92 | ADORA2A (0.63) | ADORA2AADORA3ADORA2BADORA1HSP90B1 | |
| SCHEMBL12927114 | 0.92 | ADORA2A (0.60) | ADORA2AADORA3ADORA2BADORA1HSP90B1 | |
| SCHEMBL12009349 | 0.92 | ADORA2A (0.60) | ADORA2AADORA3ADORA2BADORA1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293720-B2 | Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists | DOGWOOD PHARMACEUTICALS, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8252767-B2 | Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists | DOGWOOD PHARMACEUTICALS, INC. (US) | 2012-08-28 | — | — | US | disclosed |
| US-20110003765-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | ADENOSINE THERAPEUTICS, LLC | 2011-01-06 | — | — | US | disclosed |
| US-20100093770-A1 | THERAPEUTIC AGENT FOR GLAUCOMA CONTAINING ADENOSINE DERIVATIVE AS ACTIVE INGREDIENT | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-04-15 | — | — | US | disclosed |
| US-20090162292-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | PGXHEALTH, LLC (US) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093770-A1 | THERAPEUTIC AGENT FOR GLAUCOMA CONTAINING ADENOSINE DERIVATIVE AS ACTIVE INGREDIENT | ADORA2A, PDE2A, PRKG1 | ADORA2A 1/4885ADORA3 12/4885ADORA2B 22/4885 |
| US-20110003765-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA3 2/4885ADORA2B 4/4885 |
| US-20090162292-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA3 2/4885ADORA2B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.