Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21536696 | 0.82 | KMT2A (0.33) | CRBNTSHRKMT2ASRD5A1 | |
| SCHEMBL22549788 | 0.72 | TSHR (0.33) | CRBNTSHRKMT2ASRD5A1 | |
| SCHEMBL28251386 | 0.71 | MAPK1 (0.30) | — | |
| SCHEMBL8556280 | 0.70 | PIK3CD (0.35) | CRBNTSHRKMT2ASRD5A1 | |
| Trifluoroacetic Acid SCHEMBL4779929 | 0.68 | BACE1 (0.34) | TSHR | |
| Hydrochloric Acid SCHEMBL10768662 | 0.68 | PIK3CD (0.34) | CRBNTSHRKMT2ASRD5A1 | |
| SCHEMBL19370778 | 0.68 | TSHR (0.40) | CRBNTSHRKMT2ASRD5A1 | |
| SCHEMBL84385 | 0.68 | TSHR (0.40) | CRBNTSHRKMT2ASRD5A1 | |
| SCHEMBL26192722 | 0.68 | TSHR (0.33) | CRBNTSHRKMT2ASRD5A1 | |
| SCHEMBL8096635 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524742-B2 | Use of 5H-thioeno(3,4-c)pyrrole-4,6-dione derivatives as tumor necrosis factor inhibitor | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2013-09-03 | — | — | US | disclosed |
| US-20120220631-A1 | USE OF 5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AS TUMOR NECROSIS FACTOR INHIBITOR | TIANJIN HEMAY BIO-TECH CO., LTD. (CN) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220631-A1 | USE OF 5H-THIOENO(3,4-c)PYRROLE-4,6-DIONE DERIVATIVES AS TUMOR NECROSIS FACTOR INHIBITOR | TNF, TPMT, TNFRSF1A | CRBN 1305/4885TSHR 1010/4885KMT2A 2769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.