Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 7/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.39 |
| ▸ | RHOC | P08134 | 2/20 | 0.39 |
| ▸ | RHOA | P61586 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12006515 | 1.00 | S1PR2 (0.42) | S1PR2CACNA1GCACNA1HRHOCRHOA | |
| SCHEMBL12006216 | 1.00 | S1PR2 (0.42) | S1PR2CACNA1GCACNA1HRHOCRHOA | |
| SCHEMBL6863640 | 1.00 | S1PR2 (0.42) | S1PR2CACNA1GCACNA1HRHOCRHOA | |
| SCHEMBL12006217 | 1.00 | S1PR2 (0.42) | S1PR2CACNA1GCACNA1HRHOCRHOA | |
| SCHEMBL12015287 | 0.89 | CACNA1G (0.38) | S1PR2CACNA1GCACNA1HRHOCRHOA | |
| SCHEMBL12004714 | 0.85 | EPHX2 (0.46) | CACNA1GCACNA1HRHOCRHOACACNA1B | |
| SCHEMBL6863439 | 0.85 | EPHX2 (0.46) | CACNA1GCACNA1HRHOCRHOACACNA1B | |
| SCHEMBL6863102 | 0.85 | EPHX2 (0.46) | CACNA1GCACNA1HRHOCRHOACACNA1B | |
| SCHEMBL6863390 | 0.85 | EPHX2 (0.46) | CACNA1GCACNA1HRHOCRHOACACNA1B | |
| SCHEMBL6863159 | 0.85 | EPHX2 (0.46) | CACNA1GCACNA1HRHOCRHOACACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-08-30 | — | — | US | disclosed |
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220564-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | CACNA1G, CACNA1I, CACNA1H | S1PR2 1046/4885CACNA1G 1/4885CACNA1H 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.