Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.44 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL155622 | 0.94 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL12016863 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL152626 | 0.84 | KMT2A (0.40) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL2782550 | 0.83 | ALDH1A1 (0.42) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL2782548 | 0.83 | ALDH1A1 (0.42) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL2782588 | 0.83 | ALDH1A1 (0.42) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL153614 | 0.83 | ALDH1A1 (0.41) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL12017003 | 0.82 | ALDH1A1 (0.40) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL150575 | 0.81 | POLB (0.53) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL2780145 | 0.79 | POLB (0.42) | KDM4EALDH1A1HSD17B10GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2179998-B1 | 2-(2-OXOINDOLINE-3-YLIDENE)METHYL-5-(2-HYDROXY-3-MORPHOLIN-4-YL -PROPYL)-6,7-DIHYDRO -1H- PYRROL[3,2-C]PYRIDINE-4(5H)-ONE COMPOUNDS AND USE AS PROTEIN KINASE INHIBITORS | JIANGSU HENGRUI MEDICINE CO (CN) | 2012-08-29 | — | — | EP | disclosed |