Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202226 | 0.90 | MAPT (0.49) | MAPTALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL1201967 | 0.89 | MAPT (0.44) | MAPTALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2076565 | 0.89 | ALDH1A1 (0.49) | MAPTALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL1202350 | 0.89 | MAPT (0.44) | MAPTALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL1202485 | 0.89 | MAPT (0.52) | MAPTALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL1201675 | 0.89 | GAA (0.44) | MAPTALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL1202322 | 0.88 | ALDH1A1 (0.44) | MAPTALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL1202481 | 0.88 | GAA (0.46) | MAPTALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2076326 | 0.88 | MAPT (0.43) | MAPTALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL1201959 | 0.88 | MAPT (0.47) | MAPTALDH1A1KDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893267-B2 | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-02-22 | — | — | US | disclosed |