Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 5/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | LATS1 | O95835 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30601022 | 1.00 | CYP17A1 (0.48) | CYP17A1NAMPTRAB9AMETAP1ATR | |
| SCHEMBL23674773 | 0.88 | CYP17A1 (0.48) | CYP17A1NAMPTRAB9AMETAP1ATR | |
| SCHEMBL30411576 | 0.87 | CYP17A1 (0.45) | CYP17A1NAMPTRAB9AMETAP1ATR | |
| SCHEMBL23970808 | 0.87 | CYP17A1 (0.45) | CYP17A1NAMPTRAB9AMETAP1ATR | |
| SCHEMBL6034950 | 0.86 | CYP17A1 (0.44) | CYP17A1NAMPTRAB9AMETAP1ATR | |
| SCHEMBL15996758 | 0.86 | CYP17A1 (0.38) | CYP17A1NAMPTRAB9AKDM6BKDM4C | |
| SCHEMBL8209502 | 0.85 | CYP17A1 (0.43) | CYP17A1NAMPTRAB9AMETAP1ATR | |
| SCHEMBL18522430 | 0.84 | NAMPT (0.50) | CYP17A1NAMPTRAB9AMETAP1ATR | |
| SCHEMBL28862920 | 0.84 | DGAT2 (0.43) | CYP17A1NAMPTRAB9A | |
| SCHEMBL5746768 | 0.83 | CYP17A1 (0.46) | CYP17A1NAMPTRAB9AMETAP1LATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140249135-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2014-09-04 | — | — | US | disclosed |
| US-8822497-B2 | PIM kinase inhibitors and methods of their use | NOVARTIS AG (CH) | 2014-09-02 | — | — | US | disclosed |
| US-20120329782-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2012-12-27 | — | — | US | disclosed |
| US-8258152-B2 | N-substituted azaindoles and methods of use | GENENTECH, INC. (US) | 2012-09-04 | — | — | US | disclosed |
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION, A DELAWARE CORPORATION | 2009-08-06 | — | — | US | disclosed |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329782-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | CYP17A1 3161/4885NAMPT 1973/4885RAB9A 2364/4885 |
| US-20140249135-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | PIM1, PIM2, PIM3 | CYP17A1 4060/4885NAMPT 2779/4885RAB9A 4183/4885 |
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | CYP17A1 3161/4885NAMPT 1973/4885RAB9A 2364/4885 |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | JAK1, JAK3, JAK2 | CYP17A1 3161/4885NAMPT 1973/4885RAB9A 2364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.