Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.88 |
| ▸ | KDR | P35968 | 15/20 | 0.88 |
| ▸ | AXL | P30530 | 3/20 | 0.88 |
| ▸ | IGF1R | P08069 | 12/20 | 0.82 |
| ▸ | INSR | P06213 | 3/20 | 0.79 |
| ▸ | MST1R | Q04912 | 2/20 | 0.79 |
| ▸ | AURKA | O14965 | 1/20 | 0.79 |
| ▸ | JAK2 | O60674 | 1/20 | 0.79 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.79 |
| ▸ | ABL1 | P00519 | 1/20 | 0.79 |
| ▸ | LCK | P06239 | 1/20 | 0.79 |
| ▸ | RET | P07949 | 1/20 | 0.79 |
| ▸ | KIT | P10721 | 1/20 | 0.79 |
| ▸ | PIM1 | P11309 | 1/20 | 0.79 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.79 |
| ▸ | SRC | P12931 | 1/20 | 0.79 |
| ▸ | PRKACA | P17612 | 1/20 | 0.79 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.79 |
| ▸ | JAK1 | P23458 | 1/20 | 0.79 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12004355 | 0.94 | MET (1.00) | METKDRAXLIGF1RINSR | |
| Ningetinib SCHEMBL29392305 | 0.91 | MET (1.00) | METKDRAXLIGF1RINSR | |
| Ningetinib SCHEMBL12003786 | 0.91 | MET (1.00) | METKDRAXLIGF1RINSR | |
| Ningetinib SCHEMBL29366570 | 0.91 | MET (1.00) | METKDRAXLIGF1RINSR | |
| SCHEMBL12018173 | 0.91 | MET (0.85) | METKDRAXLIGF1RINSR | |
| Ningetinib SCHEMBL12003712 | 0.90 | MET (0.99) | METKDRAXLIGF1RINSR | |
| SCHEMBL12018170 | 0.88 | MET (0.90) | METKDRAXLIGF1RINSR | |
| SCHEMBL17081124 | 0.88 | MET (0.90) | METKDRAXLIGF1RINSR | |
| Ningetinib SCHEMBL12004019 | 0.88 | MET (0.93) | METKDRAXLIGF1RINSR | |
| Ningetinib SCHEMBL12004022 | 0.88 | MET (0.93) | METKDRAXLIGF1RINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598400-B2 | Substituted quinoline compounds and methods of use | CALITOR SCIENCES, LLC (US) | 2017-03-21 | — | — | US | disclosed |
| US-20150342945-A1 | SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-12-03 | — | — | US | disclosed |
| US-9133162-B2 | Substituted quinoline compounds and methods of use | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-09-15 | — | — | US | disclosed |
| US-20120219522-A1 | SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE | XI, Dr. Ning (US) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150342945-A1 | SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE | MKI67, MCL1, NRAS | MET 997/4885KDR 577/4885AXL 1395/4885 |
| US-20120219522-A1 | SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE | MKI67, MCL1, NRAS | MET 997/4885KDR 577/4885AXL 1395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.