Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 12/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.45 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | STK16 | O75716 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | CDK11B | P21127 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.41 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976140 | 0.84 | MAPK8 (0.61) | ROCK1MAPK8MAPK9MAPK10CIT | |
| SCHEMBL16200044 | 0.80 | ROCK1 (0.51) | ROCK1 | |
| SCHEMBL12968969 | 0.74 | ROCK1 (0.72) | ROCK1MAPK8MAPK9MAPK10 | |
| SCHEMBL19089681 | 0.74 | ROCK1 (0.54) | ROCK1MAPK8MAPK9MAPK10CIT | |
| SCHEMBL6764801 | 0.72 | ROCK1 (0.53) | ROCK1MAPK8MAPK9MAPK10CIT | |
| SCHEMBL6764818 | 0.72 | MAPK8 (0.60) | ROCK1MAPK8MAPK9MAPK10CIT | |
| SCHEMBL5096293 | 0.71 | ROCK1 (0.51) | ROCK1MAPK8MAPK9MAPK10CIT | |
| SCHEMBL5095954 | 0.69 | MAPK8 (0.57) | ROCK1MAPK8MAPK9MAPK10CIT | |
| SCHEMBL12821391 | 0.68 | ROCK1 (1.00) | ROCK1 | |
| SCHEMBL18722538 | 0.68 | ROCK1 (0.73) | ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283009-B1 | INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2012-08-29 | — | — | EP | disclosed |