Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11854035 | 1.00 | TSHR (0.36) | TSHRATMATRSPHK2SPHK1 | |
| SCHEMBL2208010 | 0.96 | TSHR (0.39) | TSHRATMATRSPHK2SPHK1 | |
| SCHEMBL9843584 | 0.88 | — | — | |
| SCHEMBL2205997 | 0.87 | GPR84 (0.43) | TSHRLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL2206803 | 0.87 | GPR84 (0.43) | TSHRLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL10457166 | 0.87 | KMT2A (0.43) | TSHRLMNANFKB1PMP22MEN1 | |
| SCHEMBL2205259 | 0.87 | GPR84 (0.43) | TSHRLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL2206691 | 0.87 | GPR84 (0.43) | TSHRLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL2206084 | 0.87 | — | — | |
| SCHEMBL1312624 | 0.85 | SPHK2 (0.56) | TSHRSPHK2SPHK1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220753-A1 | N-Terminal Dimerization Methods with Bis-Amindino Acid and Bis-Thioimidate Derivatives | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220753-A1 | N-Terminal Dimerization Methods with Bis-Amindino Acid and Bis-Thioimidate Derivatives | ERBB2, MAX, DNPEP | TSHR 1044/4885ATM 3499/4885ATR 2898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.