Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967613 | 0.81 | GSR (0.37) | CYP2C19SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL11352241 | 0.80 | AOC3 (0.41) | CYP2C19SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL8680427 | 0.80 | CYP2C19 (0.50) | CYP2C19SMN1; SMN2PPARGPPARAALDH1A1 | |
| SCHEMBL939842 | 0.80 | CYP2C19 (0.50) | CYP2C19SMN1; SMN2PPARGPPARAALDH1A1 | |
| Methane SCHEMBL28626702 | 0.79 | CYP2C19 (0.48) | CYP2C19SMN1; SMN2PPARGPPARAALDH1A1 | |
| SCHEMBL2907843 | 0.78 | GSR (0.35) | CYP2C19KDM4EALOX15GSRCYP2D6 | |
| SCHEMBL369647 | 0.77 | CYP2C19 (0.47) | CYP2C19SMN1; SMN2PPARGPPARAALDH1A1 | |
| SCHEMBL28422465 | 0.77 | CYP2C19 (0.47) | CYP2C19SMN1; SMN2PPARGPPARAALDH1A1 | |
| SCHEMBL27547164 | 0.77 | CYP2C19 (0.52) | CYP2C19SMN1; SMN2PPARGPPARAALDH1A1 | |
| SCHEMBL18236072 | 0.77 | SMN1; SMN2 (0.47) | CYP2C19SMN1; SMN2PPARGPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491926-A1 | Treatment of protein degradation disorders | President and Fellows of Harvard College (US) | 2012-08-29 | — | — | EP | disclosed |