Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.47 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.43 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203780 | 0.89 | FYN (0.53) | FYNPIM1ALDH1A1NTRK1CXCR1 | |
| SCHEMBL1203131 | 0.89 | FYN (0.53) | FYNPIM1ALDH1A1NTRK1CXCR1 | |
| SCHEMBL1202338 | 0.88 | FYN (0.66) | FYNPIM1ALDH1A1NTRK1CXCR1 | |
| SCHEMBL1203100 | 0.88 | PIM1 (0.66) | FYNPIM1ALDH1A1NTRK1CXCR1 | |
| SCHEMBL1203006 | 0.87 | ALDH1A1 (0.42) | FYNALDH1A1IRAK4CACNA1HMKNK1 | |
| SCHEMBL1203488 | 0.87 | FYN (0.52) | FYNPIM1ALDH1A1NTRK1CXCR1 | |
| SCHEMBL1203286 | 0.87 | FYN (0.53) | FYNPIM1ALDH1A1NTRK1CXCR1 | |
| SCHEMBL1203737 | 0.84 | CTNNB1 (0.46) | ALDH1A1CTNNB1TCF7L2 | |
| SCHEMBL1202810 | 0.83 | JAK3 (0.49) | FYNPIM1ALDH1A1NTRK1CXCR1 | |
| SCHEMBL1203612 | 0.83 | PIM1 (0.56) | FYNPIM1ALDH1A1NTRK1CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | PIM1, PIM3, PIM2 | FYN 403/4885PIM1 1/4885ALDH1A1 2356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.