Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 10/20 | 0.56 |
| ▸ | NPC1 | O15118 | 9/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | WNT3A | P56704 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12024335 | 0.86 | TSHR (0.60) | TSHRRAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL1842072 | 0.86 | TSHR (0.69) | TSHRRAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL18059064 | 0.81 | CTSL (0.60) | MAPTALDH1A1POLBCASP3SENP8 | |
| SCHEMBL18059053 | 0.80 | TSHR (0.61) | TSHRRAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL18059044 | 0.79 | NPC1 (0.55) | TSHRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL12023858 | 0.79 | CTSL (0.40) | TSHRRAB9ANPC1 | |
| SCHEMBL12024325 | 0.78 | NPC1 (0.54) | TSHRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1837613 | 0.78 | TSHR (0.59) | TSHRRAB9ANPC1PKMSMN1; SMN2 | |
| SCHEMBL12098605 | 0.77 | MAPT (0.72) | RAB9ANPC1PKMSMN1; SMN2MAPT | |
| SCHEMBL5675701 | 0.76 | TSHR (0.60) | TSHRRAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534658-B1 | KETONE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | INTREXON CORP (US) | 2016-09-07 | — | — | EP | disclosed |
| EP-2392561-A1 | Alpha-acylaminoketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | Intrexon Corporation (US) | 2011-12-07 | — | — | EP | disclosed |